Research

 

Facilities

The Department of Obstetrics Gynecology and Reproductive Sciences maintains its basic research facilities on the 11th floor of the Bressler Building. This facility consists of approximately 15,000 square feet of wet laboratory space and is linked to the main hospital by corridors. The space is shared by the basic scientists already noted. The equipment contained therein is state-of-the-art and allows for a full range of studies ranging from sophisticated molecular biology to whole animal instrumentation.

Research Time

This fellowship program was created on the principle of block time. There are 18 months dedicated to didactics and research. This volume of research time has allowed our fellows to design and conduct research of sufficient quality to assure completion and defense of the thesis prior to graduation from the fellowship. When assigned to the core MFM clinical service, the fellow may, clinical activity permitting, spend time in research as well.

The first year redesign of our program has definitely provided a better foundation, as well as an earlier start, for the fellows' research. It has been well received by faculty and fellows. The initial four months at the beginning of the first research block provides the fellow with a didactic foundation and introduction to the ongoing research within the division in ultrasound, and genetics. The final month of four is devoted to an introduction to basic science research under the direction of Loren Thompson, PhD.

When assigned to a research month the fellow's research shall be interrupted only by didactic sessions and attending the resident High-Risk Clinic (one-half day each per week). These clinical activities total six hours/week, well within the 10% time limit allowed. Night call remains constant throughout the fellowship as described above.

Occasional cross coverage for critical clinical activities may be required of one fellow for another's vacation or attendance at scientific or didactic meetings. This is reciprocated in kind to protect total research time.

Organized Approach to Research Development and Teaching

All fellows participate in a series of courses and lectures under the direction of the UMSOM Human Research Protections Office (HRPO) including a week-long Introduction to Clinical Investigation at UMB, the University of Miami's Collaborative IRB Training Initiative (CITI) for Biomedical Research, as well as HIPAA training and Clinical Research Billing training. HRPO also presents a series of mandatory Research Grand Rounds on such topics as Initial and Continuing Review Requirements, Unanticipated Problems Involving Risk to Research Participants or Others and Informed consent process and risks.

Initial grant writing training is provided by the UMSOM Office of Research - Career Development through a Grant Writing Workshop, a 1.5-day workshop designed to help investigators understand how to plan, organize and write a competitive grant application. Further training occurs as the division prepares its own grant requests during the twice weekly research seminars.

Selection of Special Mentor

The selection of a research mentor for each fellow is the responsibility of the Associate Program Director for Perinatal Research, and the Program Director, Jerome N Kopelman, MD. This selection takes place within the first three to sixth months of the fellowship and is subject to the approval of the fellow. The research mentor is responsible for ensuring the progress of each fellow's thesis project. Progress is monitored by the program director.

Current Research

  • Third Trimester Triage of Perinatal Risk.
    A Baschat, S Turan, R Viscardi, T Kasdaglis, J Miller, K Hashimoto.
    Unfunded

  • Fetal Middle Cerebral Artery Peak Systolic Velocity and Cordocentesis.
    M Kush,T Kasdaglis, A Baschat, C Harman, J Miller.
    Unfunded.
  • First Trimester Prediction of Placental Dysfunction by Evaluation of Maternal Hemodynamics and Pregnancy-Specific Serum Markers.
    A Baschat, C. Harman, K. Atkins, R. Atlas, J. Kopelman, M Kush, T Kasdaglis, J Miller, K Hashimoto.
    Industrial funding.
  • Comparison of Conventional Antenatal Fetal Monitoring With Wearable Long-Term Fetal/Maternal Monitor (Monica 24AN) In High Risk Pregnancies.
    A Baschat, J Miller.
    Industrial funding.
  • Twin-Twin Transfusion Syndrome Fetoscopy -- Humanitarian Device Exception
    Harman C, Baschat A, T Kasdaglis, J Miller, K Hashimoto.
    Industrial funding.
  • Fetal Adrenal Gland Volume Measurement in the Prediction of Preterm Delivery.
    Baschat A, Harman C. Miller J, Turan S, Turan M, Kasdaglis T.
    Unfunded.
  • Continuous Glucose Monitoring in Labor.
    Mighty H, Miller J.
    Industrial funding for monitoring devices only.
  • First Trimester Screening for Congenital Heart Disease Using 3-D Ultrasound.
    Baschat A, Harman C.
    Unfunded.
  • Cardiac Profile in Severe IUGR and its Association with Mortality and Neurologic Morbidity.
    Baschat A, Harman C.
    Unfunded.
  • Fetal hypoxemia and endothelium-derived nitric oxide: Chronic Hypoxia Model in the Pregnant Guinea Pig.
    Hashimoto K, Dong Y, Thompson L.
    NIH funding, departmental funding for fellows' participation.

Fellows' Presentations

HASHIMOTO

Kazumasa Hashimoto, M.D., LaShauna Evans, Gerard Pinkas and Loren P Thompson, Ph.D. Ob/Gyn/Repro Sci, Univ. of Maryland, Baltimore, MD, United States, 21201 and Physiology, Univ. of Maryland, Baltimore, MD, United States, 21201. Effect of N-acetylcysteine on fetal guinea pig liver damage via oxidative stress during chronic intrauterine hypoxia. 2010 SGI 57th Annual Scientific Meeting, March 24-27, 2010, Orlando, Florida, USA

KASDAGLIS

Kasdaglis T, Kriebs J, Harman CR, Baschat AA. Pregnancy in perinatally infected HIV patients: are outcomes any different? 29th Annual Meeting of the Society for Maternal-Fetal Medicine. Am J Obstet Gynecol. Dec 2008; 199(6A):S147.

Kasdaglis T, Kriebs J, Iqbal S, Harman CR, Baschat AA. The impact of maternal HIV on placental circulation. 29th Annual Meeting of the Society for Maternal-Fetal Medicine. Am J Obstet Gynecol. Dec 2008; 199(6A):S153.

MILLER

Miller J, Dangel A, Fahey J, Kriebs J, Mighty H. Feasibility of continuous glucose monitoring in labor. 30th Annual Meeting of the Society for Maternal-Fetal Medicine. Am J Obstet Gynecol. Volume 201, Issue 6, December 2009, 201(6A):S108.

Turan S, Turan O, Miller J, Mighty H, Harman C, Reece E , Baschat A. First trimester prenatal diagnosis of decreased fetal cardiac performance correlates with hyperglycemia in pregestational maternal diabetes 30th Annual Meeting of the Society for Maternal-Fetal Medicine. Am J Obstet Gynecol. Dec 2009; 201(6A):S26.

Miller J, Turan S, DeVeciana M, Harman CR, Baschat AA. First trimester detection of fetal anomalies in pregestational diabetes. 29th Annual Meeting of the Society for Maternal-Fetal Medicine. Am J Obstet Gynecol. Dec 2008; 199(6A):S207.

Miller J, Ty-Torredes K, Schindel M, Harman CR, Baschat AA. Non-invasive detection of significant uterine activity. 29th Annual Meeting of the Society for Maternal-Fetal Medicine. Am J Obstet Gynecol. Dec 2008; 199(6A):S225.

Turan S, Turan O, Jefferies S, Miller J, Harman CR, Baschat AA. Reproducibility of four dimensional ultrasound with spatiotemporal image correlation (STIC) in the first trimester detection of cardiac anomalies. 18th World Congress on Ultrasound in Obstetrics and Gynecology, Ultrasound Obstet Gynecol Aug 2008; 32: 333.

Baschat AA, Ty-Torredes K, Miller J, Adams L, Harman CR. Fetoscopic laser ablation for twin-twin transfusion syndrome -- outcomes with a modified technique. 29th Annual Meeting of the Society for Maternal-Fetal Medicine. Am J Obstet Gynecol. Dec 2008; 199(6A): S133.

Ty-Torredes K, Turan O, Gungor S, Miller J, Adams L, Harman CR, Baschat AA. Outcome of fetoscopic laser ablation for twin-twin transfusion syndrome in relation to procedure details. 29th Annual Meeting of the Society for Maternal-Fetal Medicine. Am J Obstet Gynecol. Dec 2008; 199(6A):S183.

ADAMS

Adams L, Turan O, Yazdani M, Kopelman J, Harman CR, Baschat AA. Isolated first trimester uterine artery screening fails to predict severe cases of placental dysfunction. 18th World Congress on Ultrasound in Obstetrics and Gynecology, Ultrasound Obstet Gynecol Aug 2008; 32: 345.

Baschat AA, Adams L, Turan O, Kopelman J, Jenkins C, Atlas R, Blitzer M, Harman CR. First trimester integrated screening for fetal growth restriction. 29th Annual Meeting of the Society for Maternal-Fetal Medicine. Am J Obstet Gynecol. Dec 2008; 199(6A):S184.

Baschat AA, Ty-Torredes K, Miller J, Adams L, Harman CR. Fetoscopic laser ablation for twin-twin transfusion syndrome - outcomes with a modified technique. 29th Annual Meeting of the Society for Maternal-Fetal Medicine. Am J Obstet Gynecol. Dec 2008; 199(6A):S133.

Ty-Torredes K, Turan O, Gungor S, Miller J, Adams L, Harman CR, Baschat AA. Outcome of fetoscopic laser ablation for twin-twin transfusion syndrome in relation to procedure details. 29th Annual Meeting of the Society for Maternal-Fetal Medicine. Am J Obstet Gynecol. Dec 2008; 199(6A):S183.

Lan Adams, Ozhan Turan, Maryam Yazdani, Christopher Harman, Ahmet Baschat. First Trimester Uterine Artery Doppler Pulsatility Index (Ua Pi) Screening Will Not Predict All Severe Cases Of Placental Dysfuction. SMFM 28th Annual Scientific Meeting February 2, 2008 Dallas, Texas USA.

IQBAL

Kasdaglis T, Kriebs J, Iqbal S, Harman CR, Baschat AA. The impact of maternal HIV on placental circulation. 29th Annual Meeting of the Society for Maternal-Fetal Medicine. Am J Obstet Gynecol. Dec 2008; 199(6A):S153.

Sara Iqbal, Christopher Harman, Lindsay Alger, Sadettin Gungor, Jan Kriebs, Ozhan Turan, Ahmet Baschat, Predictors of Fetal Growth Restriction (FGR) in Maternal HIV Disease. 28th Annual Meeting. Society for Maternal-Fetal Medicine, January 28, 2008 - February 2, 2008, Dallas, Texas.

Iqbal S, Harman C, Turan O, Alger L, Kriebs J, Baschat A. Choosing antiretroviral agents to treat HIV positive women in pregnancy. American Journal of Obstetrics and Gynecology. 27th Annual Meeting, Society for Maternal-Fetal Medicine, February 5-10, 2007, San Francisco, CA

MANOGURA

Turan O, Manogura A, Oh C, Kush M, Harman C, Baschat A. First trimester placental blood flow resistance in pregestational diabetes 27th Annual Meeting, Society for Maternal-Fetal Medicine, February 5-10, 2007, San Francisco, CA.

Manogura A, Kush M, Harman C, Baschat A. When to screen for fetal growth abnormalities in pre-gestational diabetic pregnancies. American Journal of Obstetrics and Gynecology. 27th Annual Meeting, Society for Maternal-Fetal Medicine, February 5-10, 2007, San Francisco, CA.

OH

Turan, Ozhan; Manogura, Anita; Oh, Chien; Kush, Michelle; Harman, Christopher; Baschat, Ahmet. First Trimester Placental Blood Flow Resistance in Pregestational Diabetes: 27th Annual Meeting, Society for Maternal-Fetal Medicine, February 5-10, 2007, San Francisco, CA.

Baschat, Ahmet; Oh, Chien; Kush, Michelle; Gembruch, Ulrich; Harman, Christopher. Fetal Syndrome of Hemolysis and Low Platelets (Help): A Complication Of Placental Dysfunction: 27th Annual Meeting, Society For Maternal-Fetal Medicine, February 5-10, 2007, San Francisco, CA.

Oh C, Dong Y, Thompson L. Chronic hypoxia increases IL-6, TNF-, and matrix metalloproteinases (MMP2 and MMP9) expression of fetal guinea pig hearts. 27th Annual Meeting, Society for Maternal-Fetal Medicine, February 5-10, 2007, San Francisco, CA.

Oh, Chien; Harman, Christopher; Baschat, Ahmet. First Trimester Ductus Venosus Doppler: An Independent Risk Factor for Adverse Pregnancy Outcome. 27th Annual Meeting, Society for Maternal-Fetal Medicine, February 5-10, 2007, San Francisco, CA.

Fellows' Publications

KASDAGLIS

Kasdaglis T, Aberdeen G, Turan O, Kopelman J, Atlas R, Jenkins C, Blitzer M, Harman C, Baschat A. Placental growth factor in the first trimester -- relationship with maternal factors and placental Doppler. Ultrasound in Obstetrics and Gynecology. Published Online: 5 Jan 2010.

Baschat A, Kasdaglis, T, Aberdeen, G, Turan O, Kopelman, J, Atlas R, Jenkins C, Blitzer M, Harman, C. First-Trimester Angiopoietin-2: Relationships with Maternal and Placental Characteristics. American Journal of Perinatology. 27(1):9-14, January 2010.

MILLER

Miller JL, Harman CR, Weiner CP, Baschat AA. Perinatal outcomes after second trimester detection of amniotic fluid viral genome in asymptomatic patients. J Perinat Med 2008; 36: 500-04.

Turan S, Miller J, Baschat AA. Integrated testing and management in fetal growth restriction. Semin Perinatol 2008; 32: 194-200.

Miller J, Turan S, Baschat AA. Fetal growth restriction. Semin Perinatol 2008; 32: 274-80.

ADAMS

Adams LL, Gungor S, Salim M, Harman CR, Baschat AA. Regression of fetal heart block and myocardial echogenicity with steroid therapy in maternal Sjogrens syndrome. Ultrasound Obstet Gynecol 2008; 32: 839-40.

IQBAL

Iqbal S, Kriebs J, Harman C, Gungor S, Alger S, Turan O, Kopelman J, Malinow A, Baschat AA. Protease Inhibitor Therapy and Fetal Growth Potential in HIV-Positive Women. Am J Perinatol 2008, 25: 335-39.

MANOGURA

Manogura AC, Turan O, Kush ML, Berg C, Bhide A, Turan A, Moyano D, Bower S, Nicolaides KH, Galan HL, Muller T, Thilaganathan B, Gembruch U, Harman CR, Baschat AA. Predictors of necrotizing enterocolitis in preterm growth-restricted neonates. Am J Obstet Gynecol 2008; 198: 638. e1-638.e5.

Scrandis DA, Langenberg P, Tonelli LH, Sheikh TM, Manogura AC, Alberico LA, Hermanstyne T, Fuchs D, Mighty H, Hasday JD, Boteva K, Postolache TT. Prepartum Depressive Symptoms Correlate Positively with C-Reactive Protein Levels and Negatively with Tryptophan Levels: A Preliminary Report. Int J Child Health Hum Dev. 2008 Aug;1(2):167-174.

OH

Oh C, Dong Y, Liu H, Thompson LP. Intrauterine hypoxia upregulates proinflammatory cytokines and matrix metalloproteinases in fetal guinea pig hearts. American Journal of Obstetrics & Gynecology, 2008 Jul;199(1):78.e1-6. Epub 2008 Feb 15.

Oh C, Dong Y, Harman CR, Mighty H, Kopelman J, Thompson L. Chronic hypoxemia differentially increases glutathione content and g-glutamyl cysteine synthetase expression in fetal guinea pig organs. Early Hum Devel. 2008 84:121-7.

Oh C, Harman C, Baschat AA. Abnormal first-trimester ductus venosus blood flow: a risk factor for adverse outcome in fetuses with normal nuchal translucency. Ultrasound Obstet Gynecol. 2007 Aug;30(2):192-6.

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This page was last updated: August 6, 2014

         
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