Recruitment for Clinical Studies

Clinical trials are studies designed to find new and better ways to treat patients with Lung Transplant rejection. Dr. Iacono is currently conducting the clinical trials listed below.

Studies open frequently. If interested in the latest information regarding our studies, please call Jen Davis, BS RRT 410-328-1473

Clinical Trial Detail -- Liposomal Cyclosporine for Inhalation

Definition: This study is looking at inhaled Liposomal Cyclosporine versus Standard of Care in patients with Lung transplant rejection.  Oral Cyclosporine is a very common immunosuppressant medication used in Lung Transplant.  The goal of this study is to give this drug by inhalation. The idea behind this is that cyclosporine given by inhalation will be given directly to the transplanted lung.  Having direct topical effect will help it from touching other organs. Limiting the contact on the other organs will decrease the negative side effects.

Duration:  Participants will be a part of the study for one year of time.  This will include a combination of telephone calls and clinic visits.  More details of study procedures can be discussed over the phone or by email.

Reimbursements:  Participants will be reimbursed $25 per visit to help offset transportation costs. 

Principal Investigator: Aldo Iacono, MD

Eligibility: Participants must have been diagnosed with lung transplant rejection

Contact: For more information or to inquire about participating, call the Research Coordinator, Jen Davis, BS RRT 410-328-1473 or email at jdavis2@medicine.umaryland.edu


Clinical Trial Detail -- Cyclosporine Inhalation Solution (CIS) in Lung Transplant and Hematopoietic Stem Cell Transplant Recipients for the Treatment of Bronchiolitis Obliterans

Study Description: Inhaled cyclosporine (CIS) achieves higher concentrations of cyclosporine in the lungs and lower concentrations of cyclosporine in the blood than oral cyclosporine. Therefore, it could have advantages over conventional oral immunosuppressive therapies used to treat this disorder. Researchers are interested in testing whether inhaled cyclosporine therapy could be used as a safe and effective treatment for bronchiolitis obliterans or bronchiolitis obliterans syndrome occurring after bone marrow/blood stem cell or lung transplants. 

Principal Investigator: Nicole Gormley, MD, NIH Clinical Center, Bethesda, MD & Associate Investigator: Aldo Iacono, MD

Eligibility: Individuals between 10 and 80 years of age who have been diagnosed with bronchiolitis obliterans (chronic rejection) or bronchiolitis obliterans syndrome after blood or lung transplants

Contact: For more information or to inquire about participating, call Jen Davis, BS RRT 410-328-1473


Volunteer for a research study that compares the immune system of smokers and non-smokers

The Division of Pulmonary and Critical Care Medicine is initiating a study comparing the immune systems of smokers to non-smokers.

To be eligible, you must be between the ages 21-55 years old. In addition, you must either be a life-long non-smoker or actively be smoking 1 pack per day for 5 or more years. Compensation would be $180 and expenses.

Volunteers would undergo:

  • Short 15 minute visit to perform pulmonary function tests (blow into a tube) and talk about their medical history.

  • Bronchoscopy with simple BAL (insertion of fiberoptic camera into lungs and washing fluid)

  • Insertion of peripheral intravenous for procedure with removal of 100cc of blood.

For more information please contact: University of Maryland Airways Research Center 410 706-LUNG (5864).


Do you have a nagging cough due to smoking?

If so, you may have Chronic Obstructive Pulmonary Disease (COPD) (a smoking related lung disorder). We are looking for people with COPD to participate in clinical trials which evaluate new treatments.

Qualified participants will receive:

  • FREE study related exams

  • FREE study medication

  • FINANCIAL COMPENSATION

To find out if you qualify, please call the U of MD Airways Research Center 410-706-LUNG (5864). You must be 30 or older to participate.


You play as hard as you work...
But you shouldn't have to work to breathe.

We're working for better asthma treatments.

Our clinic is conducting a clinical research study for teenagers and adults who have asthma. This study is testing the effectiveness or two marketed medications for the treatment of asthma.

You may be able to participate if you are at least 12 years of age and have a history of asthma. Study staff will review additional criteria with you.

You will be asked to come to the clinic for 11 study visits over approximately 9 months. All study-related medical evaluations and study medications are provided to qualified participants at no cost.

For more information please contact: University of Maryland Airways Research Center 410 706-LUNG (5864).

Studies open frequently. If interested in the latest information regarding our studies, please call 410-328-1473.

This page was last updated: July 26, 2013

         
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