Stefanie Vogel, Ph.D.
Professor of Microbiology and Immunology, Professor of Medicine
Microbiology and Immunology
- PhD - University of Maryland 1977
- 1977 - 1980 Postdoctoral Fellow; National Institute of Dental Research; Laboratory of Microbiology and Immunology, NIH
- Professor, Dept. of Microbiology and Immunology (Primary appointment)
- Professor of Medicine, (Secondary appointment)
- Cellular and molecular mechanisms by which endotoxin mediates its effects
- Analysis of TLR gene manifestations and cytokine biology
- Role of endogenous and exogenous interferons in macrophage development
The innate immune system provides a first line of defense against microbial infection and prepares the host for the induction of an antigen-specific, adaptive immune response. Central to the ability of the phagocytic leukocytes of the immune system to recognize and respond to bacteria and viruses are evolutionarily conserved “pattern recognition receptors” that sense foreign pathogens and enable the phagocytic cell to engulf the microbes or to release inflammatory mediators that facilitate clearance of organisms.
Dr. Vogel's research is focused on the capacity of macrophages to respond to bacterial products such as the endotoxic lipopolysaccharide (LPS) of Gram negative bacteria. Their studies on the role of Toll-like receptors (TLRs) in this process has led to the dissection of intracellular signaling pathways that define TLR responses to different pathogens, suggesting that these receptors have evolved to enable the host to respond appropriately to specific pathogens.
In addition to examining the expression of a variety of proinflammatory genes as a consequence of exposure of macrophages to LPS and other microbial products, the Vogel laboratory is also actively studying mechanisms by which the inflammatory response to infection is controlled in mice and in humans. Specifically, they have utilized a paradigm of in vitro and in vivo “endotoxin tolerance” in which macrophages or mice exposed to a relatively low dose of LPS become transiently refractory to subsequent challenge to a variety of TLR agonists. An analysis of the kinase and DNA binding activities of signaling components involved in the TLR4 and TLR2 signaling pathways have been examined systemmatically by her group, in addition to studies that demonstrate dysregulated interactions among intracellular proteins required for this activation. The role of cytoskeletal derrangement in this process is also being evaluated using confocal microscopic approaches and immunohistochemical staining for analyzing the coordinate disruption of TLR signaling components.
Lastly, the Vogel laboratory has also pursued mechanisms of inflammatory damage in other animal models where cytokines figure centrally in disease pathology (e.g., stroke, encephalitic viruses, cecal ligation and puncture-induced polymicrobial sepsis, hemorrhagic shock, Respiratory Syncytial Virus infection, and others). The Vogel laboratory combines a unique collection of molecular, genetic, and biochemical approaches to tackle these sorts of questions. Dr. Vogel has joined UMB in May 2002, but has had 22 years of experience with graduate students at Uniformed Services University of the Health Sciences, Bethesda, MD, where she contributed to a training grant and successfully mentored 6 Ph.D. students and one M.S. student during her 22 year tenure at USUHS. She has a large group of people in the lab (students, post-doctoral fellows, and faculty) and welcomes applications from qualified and interested individuals