Dr. Goldblum

Simeon E. Goldblum, M.D. Simeon E. Goldblum, M.D.
Professor of Medicine, University of Maryland
Professor of Pathology: University of Maryland

Department: Division
Medicine: Infectious Disease
Medicine: Division of Pulmonary and Critical Care (secondary)

Fellowship: University of New Mexico School of Medicine

Biography:

  • Attending, Division of Infectious Diseases
  • Associate Director of Basic Science, The Mucosal Biology Research Center, University of Maryland School of Medicine

Current Research Interest:

  • Host Responses to Infectious Diseases
  • Interleukin-1, Tumor Necrosis Factor
  • Endothelial Barrier Function
  • Endothelial Cytoskeletal Organization
  • LPS Presentation to Host Target Tissues
  • Counteradhesive Proteins (SPARC/osteonectin, Thrombospondin-1)
  • Protein Tyrosine Phosphorylation signaling events
  • Intercellular Junctions (zonula adherens)
  • Zonula Occludins Toxin
  • Transendothelial Migration of Leukocytes
  • Sialidases
  • Angiogenesis

Our laboratory is interested in the intracellular effector mechanisms that couple specific receptor-ligand interactions with opening of the pulmonary vascular endothelial paracellular pathway. More specifically, we have focused on the tyrosine phosphorylation signaling events that regulate protein-protein interactions within the zonula adherens multiprotein complex, actin organization, and cell-cell homophilic adhesion.

Our studies have included bacterial constituents (e.g., lipopolysaccharide or endotoxin, staphylococcal enterotoxin B) and members of a family of novel counteradhesive proteins (e.g., thrombospondin-1 and SPARC i.e., Secreted Protein Acidic and Rich in Cysteine). More recently, we have begun to study receptor and nonreceptor protein tyrosine phosphatases (PTPs) that associate with and restrain tyrosine phosphorylation of zonula adherens proteins with a focus on ZA-associated PTPs including PTPmu.

In a collaborative project with the laboratory of Dr. Alan S. Cross, we are engaged in studies of endogenous sialidases and the role of desialylation of surface structures on neutrophils and the endothelial barrier and how these events regulate neutrophil adherence to and migration across the endothelium. Most recently, we have studied the regulatory role that sialidases have on airway epithelial cell signaling and bacterial adhesion. In another collaboration with the laboratory of Dr. Alessio Fasano, we are studying the signaling events that couple stimulation by either the prokaryotic protein, zonula occludin toxin (ZOT), or the eukaryotic homologue, zonulin, with tight junction disassembly.

Current Research Funding:

  • 2006-2011 National Institutes of Health: "Thrombospondin-1 Opens Endothelial Paracellular Pathway via EGFR/ErbB2 Activation." R01 HL 084223A
  • 2008-2013 National Institute of Health: "Endotoxin/TLR4 Signaling Regulates Lung Endothelial Paracellular Pathway." R01 HL089179-01A1
  • 2009-2013 Department of Veterans Affairs: "Endotoxin/TLR4 Signaling Regulates Lung Endothelial Paracellular Pathway." VA Merit Review
  • 2008-2013 National Institute of Health: "Zot, Zonulin, and Pathophysiology of Intestinal Tight Junctions." R01DK048373-11A1
  • 2006-2011 National Institute of Health: "Stabilized Microtubule Protrusions in Detached Mammary Epithelial Cells." R01 CA124704-01
  • 2007-2012 National Institute of Health: "Role of Sialidase in Pulmonary Host Defenses and Acute Lung Injury." R01 HL086933
  • 2008-2013 National Institute of Health: "The Mechanism of Fever-enhanced Acute Lung Injury." R01HL69057

Education:

  • MD - University of Pittsburgh School of Medicine, (1973)
  • House Staff Training: Montefiore Hospital Medical Center; Einstein College of Medicine
  • Fellowship Training: University of New Mexico School of Medicine

Contact Information:
1-800-373-4111 (physicians only)
1-800-492-5538 (patients only)
1-410-328-8919 (news media only)

This page was last updated: July 26, 2013

         
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