This shared service provides a major resource to members of the UMGCC, bridging both the clinical and basic sciences, with the goal of assisting
in translating basic research to the clinic.
Services that are offered as part of the Tissue Bank Shared Service include:
- The collection of human tissues, neoplastic and normal, from surgical pathology
specimens resected at UMMC and bone marrow aspirates from the Cancer Center
patients for the use by UMGCC members and the UMB community.
- The initial preparation of tissue samples is done according to established
protocols. The following techniques -- touch imprint preps, snap freezing,
controlled freezing, and fixation with paraffin embedding -- are routinely
done. Density gradient separation of bone marrow is performed to isolate white
blood cells. Blood is separated into its components, that are then frozen.
- Banking of surplus tumor and normal tissue in the form of snap frozen tissue,
frozen touch imprint preparations, and paraffin embedded fixed material. This
is a resource for retrospective studies. The provision of such tissues, including
histological sections of frozen and fixed tissue, is only to approved investigators.
- A tissue database is maintained, which includes harvested tissue. There is
appropriate quality assurance activities and interfacing with Pathology Department
and UMGCC databases to provide optimal and accurate clinical and pathological
- The Tissue Bank Oversight Committee approves requests for tissue. This committee
reviews proposals to determine the minimum useful amounts of tissue required,
the manner in which the tissue is to be supplied, restrictions as to how the
material must be supplied, and whether IRB and other approvals have been granted.
- All collection activities are conducted in a manner that will ensure that
priority is given to accurate pathologic diagnosis, that the patient confidentiality
is protected, and that investigators have appropriate authorization for tissue