An in-depth report on the causes, diagnosis, treatment, and prevention of gout.
Gout is a painful inflammatory arthritis condition caused by deposits of uric acid crystals in the joints and soft tissues. The painful attacks often begin at night and may last for a week.
8.3 million people in the U.S. have gout. This number is growing because of an aging population, the rise in obesity, increasing numbers of people who also have other conditions such as heart disease, kidney disease, and/or diabetes. The use of diuretics by persons with cardiovascular disease is another cause of the increase in gout.
Treatment and Management
- Medications are aimed at treating acute attacks by reducing pain and inflammation in the joints and other tissues. Medications also prevent future attacks by lowering uric acid in the body.
- Lifestyle changes are important in preventing attacks and managing the condition. Measures include losing weight, limiting foods and beverages that have the chemical purine, and limiting alcohol.
Gout is a painful and common type of arthritis. It is caused when there is too much uric acid in the blood. This is called hyperuricemia. Uric acid is a waste product in the body and is normally excreted through urine. Buildup of uric acid results in needlelike crystals forming in the joints, soft tissues, and organs.
Cases of gout have increased in recent years. This increase is likely due to an aging population, dietary and lifestyle changes, greater use of medicines, such as diuretics (water pills), all of which can lead to a high uric acid level in the body.
Click the icon to see an animation about gout.
How Hyperuricemia and Gout Develop
Metabolism of Purines. The process leading to hyperuricemia and gout begins with the metabolism, or breakdown, of purines. Purines are compounds that are important for energy. Purines can be divided into two types:
The process of breaking down purines results in the formation of uric acid in the body. Most mammals, except humans, have an enzyme called uricase. Uricase breaks down uric acid so it can be easily removed from the body. Because humans lack uricase, uric acid is not easily removed and can build up in body tissues.
Uric Acid and Hyperuricemia. Purines in the liver produce uric acid. The uric acid enters the bloodstream. Most of the uric acid goes through the kidneys and is excreted in urine. The remaining uric acid travels through the intestines where bacteria help break it down.
Normally these processes keep the level of uric acid in the blood below 6.8 mg/dL. But sometimes the body produces too much uric acid or removes too little. In either case, the level of uric acid increases in the blood. This condition is known as hyperuricemia.
If uric acid reaches 7 mg/dL or higher, needlelike crystals of a salt called monosodium urate (MSU) may form. The higher the level of uric acid, the higher the risk of crystal formation. As crystals build up in the joints, they trigger inflammation and pain. These are the symptoms of gout.
Symptoms of gout depend on the stage of the disease. Gout can be divided into four stages:
- Asymptomatic hyperuricemia
- Acute gouty arthritis
- Intercritical gout
- Chronic tophaceous gout
Asymptomatic means there are no symptoms. Increase in blood uric acid is the first stage of gout. This stage may last 30 years or more.
Note: Hyperuricemia does not always lead to gout. Less than 20% of cases devleop into arthritic gout disease.
Symptoms of Acute Gouty Arthritis
Acute gouty arthritis occurs when the first symptoms of gout appear. Sometimes the first signs of gout are brief twinges of pain (petit attacks) in an affected joint. These attacks can last several years before the full-blown condition occurs.
Symptoms of acute gouty arthritis often start in one joint and include any of the following:
Severe pain at and around the joint: may feel like "crushing" or a dislocated bone; physical activity and even the weight of bed sheets may be unbearable; usually takes 8 to 12 hours to develop; occurs late at night or early in the morning and may wake you up
Swelling that may extend beyond the joint
Warmth over the joint
Red, shiny, tense skin over the affected area, which may peel after a few days
Chills and mild fever, loss of appetite, not feeling well in general
Monoarticular Gout. Gout that occurs in one joint is called monoarticular gout. About 60% of all first-time monoarticular gout attacks in middle-aged adults occur in the big toe. This is known as podagra. Symptoms can also occur in other locations such as the ankle or knee.
Polyarticular Gout. If more than one joint is affected, the condition is known as polyarticular gout. Multiple joints are affected in only 10% to 20% of first attacks. Older people are more likely to have polyarticular gout. The most frequently affected joints are the foot, ankle, knee, wrist, elbow, and hand. The pain usually occurs in joints on one side of the body and it is usually, though not always, in the lower legs and the feet. People with polyarticular gout are more likely to have a slower onset of pain and a longer delay between attacks. People with polyarticular gout are also more likely to experience low-grade fever, loss of appetite, and a general feeling of poor health.
An untreated attack peaks 24 to 48 hours after symptoms first appear and goes away after 5 to 7 days. Some attacks last only hours, while others go on for as long as several weeks. Though symptoms can subside, the crystals are still present and future attacks are likely to occur.
Intercritical gout is the term used to describe the periods between attacks. The first attack is usually followed by a complete disappearance (remission) of symptoms. But, untreated, gout nearly always returns. Over two-thirds of patients have at least one more attack within 2 years of the first attack. By 10 years, over 90% of patients are likely to have more attacks.
Symptoms of Chronic Tophaceous Gout
Chronic Tophaceous Gout and Tophi. After several years, persistent gout can develop into a condition called chronic tophaceous gout. This long-term condition often produces tophi. These are solid deposits of MSU crystals that form in the joints, cartilage, bones, and elsewhere in the body. In some cases, tophi break through the skin and appear as white or yellowish-white, chalky nodules that have been described as looking like crab eyes.
Click the icon to see an image of tophi gout.
Without treatment, tophi develop about 10 years after the onset of gout, although the occurrence can range from 3 to 42 years. Tophi are more likely to appear early in the course of the disease in older people. In the elderly, women are at higher risk of developing tophi than men. Persons who have had an organ transplant and are on the medicine cyclosporine also have a high risk of developing tophi.
Chronic Pain. When gout remains untreated, the intercritical periods become shorter and shorter and the attacks, although sometimes less intense, can last longer. In about 10 to 20 years gout becomes a chronic disorder with constant low-grade pain and mild or acute inflammation. Gout may later affect several joints, including those that may have been free of symptoms at the start of the disorder. In rare cases, the shoulders, hips, or spine are affected.
Location of Tophi. Tophi may form in the following locations:
Curved ridge along the edge of the outer ear
Elbow or knee
Hands or feet -- older patients, particularly women, are more likely to have gout in the small joints of the fingers.
Around the heart and spine (rare)
Tophi are usually painless. But they can cause pain and stiffness in the affected joint. In time, they can also wear aways cartilage and bone and destroy the joint. Large tophi under the skin of the hands and feet can cause severe deformities.
Uric Acid Nephrolithiasis (Kidney Stones). Persons who have kidney stones that formed from uric acid are more likely to have a higher level of uric acid in their blood than in their urine. This suggests that hyperurecemia is responsible for this type of kidney stone.
Not all kidney stones in patients with gout are made of uric acid. Some are made of calcium oxalate, calcium phosphate, or substances combined with uric acid. Uric acid stones can also form in a person who does not have gout or hyperuricemia.
Chronic Uric Acid Interstitial Nephropathy. Chronic uric acid interstitial nephropathy occurs when crystals slowly form in the structures and tubes that carry fluid from the kidney. This condition is reversible and not likely to injure the kidneys.
Kidney Failure. Sudden overproduction of uric acid can sometimes block the kidneys and cause them to fail. This occurrence is very rare but can develop after any of the following:
- Chemotherapy for leukemia or lymphoma, particularly acute forms of the disease
- Other cancers, such as breast cancer and lung cancer
- Epileptic seizures
- Pregnancy related preeclampsia or eclampsia
- Use of medications to prevent kidney transplant rejection, such as cyclosporine
Causes and Risk Factors
Gout is considered either primary or secondary, depending on the causes of the high uric acid level in the blood (hyperuricemia).
Nearly all cases of primary gout cases are idiopathic. This means that the cause of the hyperuricemia cannot be determined. Primary gout is most likely the result of a combination of genetic, hormonal, and dietary factors. Secondary gout is caused by medicines or by medical conditions other than a metabolic disorder.
The following factors increase the risk of gout:
Family history of the condition; genetic predisposition
Medicines, including diuretics (water pills), low-dose aspirin, cyclosporine, or levodopa
- Binge drinking
Other serious illness
People with gout are at an increased risk of having metabolic syndrome. Metabolic syndrome is a collection of health problems, such as abdominal obesity, high blood pressure, and low "good" cholesterol. This syndrome increases a person's risk of heart disease and stroke. Therefore, lifestyle changes are an important aspect of preventing gout and improving overall health.
Each risk factor is discussed below.
Middle-Aged Adults. Gout usually occurs in men in the mid-40s. Men of this age group who have gout are often obese, have high blood pressure, unhealthy cholesterol levels, and drink large amounts of alcohol.
Elderly. Gout occurs equally in men and women. In this group, gout is most often associated with kidney problems and the use of diuretics. It is less often associated with alcohol use.
Children. Gout in children is uncommon except for rare inherited genetic disorders that cause hyperuricemia.
Men. Men are at much higher risk of gout than women. In men, uric acid level normally rises at puberty. In some American men, the level is higher than normal, which means they have hyperuricemia. Gout symptoms appear after 20 to 40 years of persistent hyperuricemia. So men who develop gout usually experience their first attack between the ages of 30 and 50.
Women. Before menopause, women have a much lower risk of gout than men. This may be because estrogen causes more uric acid to be excreted by the kidneys. Only about 15% of gout cases in women occur before menopause. After menopause the risk increases. At age 60 the risk of gout in men and women is equal. After age 80, gout occurs more often in women.
Family History and Genetics
About 20% of persons with gout have family histories of this condition. Several genes are linked to uric acid metabolism and gout. Some people have a defective protein (enzyme) that interferes with the way the body breaks down purines.
Scientists have found a clear link between body weight and uric acid level. The higher a person's weight (body mass index, or BMI), the higher the chance of developing gout. Children who are obese may have an increased risk of gout as adults.
Thiazide diuretic medicines, or water pills, are used to control high blood pressure (hypertension). These medicines are strongly linked to the development of gout. Many older patients who develop gout take diuretics.
Other medicines can also increase uric acid level and raise the risk of gout. These include:
Drinking excessive amounts of alcohol can raise the risk of gout. Beer is most strongly linked to gout, followed by spirits. Moderate wine intake does not seem to increase the risk of developing gout.
Alcohol use is highly associated with gout in younger adults. Binge drinking particularly increases uric acid level. Alcohol appears to play less of a role among elderly patients, especially among women with gout.
Alcohol increases uric acid level in the following three ways:
Provides an additional dietary source of purines (the compounds from which uric acid is formed)
Intensifies the body's production of uric acid
Lowers the kidneys' ability to excrete uric acid
Long-term exposure to lead is associated with buildup of uric acid and a high incidence of gout.
Persons who have had a kidney transplant have a high risk of gout. Other organ transplants, such as heart and liver, also increase the risk of gout. This is because the surgery itself raises the risk of gout, as does the medicine cyclosporine used to prevent rejection of the transplanted organ. Cyclosporine also interacts with indomethacin, a common gout medicine.
The kidneys are responsible for removing waste from the body, regulating electrolyte balance and blood pressure, and stimulating red blood cell production.
Treatment of other conditions can lead to a high level of uric acid in the blood, resulting in a gout attack. These conditions include:
Triggers are events or conditions that can set off a gout attack. Certain risk factors, including a purine-rich diet, are also considered triggers. Triggers include:
- Joint injury
- Too much alcohol or purine-rich foods
- Severe illness or infection
- Sudden weight loss, crash dieting
- Radiation therapy
- Using certain drugs
The first step in diagnosing gout is to determine which joints are affected. A physical examination and medical history can help confirm or rule out gout. For example, gout is more likely if arthritis first appears in the big toe.
The speed of the onset of pain and swelling is also important. Symptoms that take days or weeks (rather than hours) to develop probably point to a problem other than gout.
Unusal enlargements in joints that had been affected by previous injury or osteoarthritis are possible signs of gout. This is especially true in older women who take diuretics (water pills).
Examination of Synovial Fluid
Synovial fluid examination is the most accurate method for diagnosing gout. The synovial fluid is the lubricating liquid that fills the synovium. This is the membrane that surrounds a joint and creates a protective sac. The fluid cushions joints and supplies nutrients and oxygen to the cartilage surface that coats the bones. This exam also helps detect gout between attacks.
A procedure called arthrocentesis is performed. The health care provider uses a needle attached to a syringe to draw out fluid from the affected joint. This is called aspiration. The fluid sample is sent to a laboratory. If monosodium urate (MSU) crystals are found, it is very likely the diagnosis is gout. Aspiration sometimes eases symptoms by reducing swelling and pressure on the tissue surrounding the joint.
Synovial fluid analysis is a method to look at the fluid that cushions a joint. It is done to help diagnose and treat joint-related problems such as gout.
Blood Test for Uric Acid Level
A blood test may be done to measure uric acid level in the blood. Since uric acid level can rise and fall during an attack, a blood test may not be accurate at that time. Some doctors may wait until several days after the attack to order a blood test.
Sometimes a urine test is done to check the amount of uric acid in a patient's urine. If uric acid in the urine is higher than a certain value, further tests for an enzyme defect or other cause of gout will be ordered. A high level of uric acid in the urine means that the patient is more likely to develop uric acid kidney stones.
X-Rays. X-rays do not usually show problems during the early stages of gout. X-rays are more often used in chronic gout. X-rays may help find other problems with symptoms similar to gout. Tophi can be seen on x-rays before they can be found during a physical exam.
Advanced Imaging Techniques. In very rare cases, advanced imaging techniques are used for identifying tophi. These techniques include computed tomography (CT), magnetic resonance imaging (MRI), and Doppler ultrasonography.
Ruling Out Other Disorders
As part of the diagnosis, other disorders that cause gout-like symptoms or cause hyperuricemia should be ruled out. In general, it is easy to distinguish acute gout that occurs in one joint from other arthritic conditions. The two disorders that may confuse this diagnosis are pseudogout and septic arthritis. Pseudogout is a condition most likely to be confused with gout.
Chronic gout can often resemble rheumatoid arthritis. Other conditions may at some point in their course resemble gout.
Pseudogout (Calcic Gout)
Pseudogout is also called calcic gout or calcium pyrophosphate dihydrate deposition disease. It is a common inflammatory arthritis in older adults. It is similar to gout. Like gout, pseudogout is caused by deposits of crystals in and around the joints. But the type of crystals of pseudogout are calcium pyrophosphate dihydrate.
Symptoms of pseudogout resemble gout in some ways, but there are differences:
The first attack usually affects the knee. Other joints commonly affected are the shoulders, wrists, and ankles. At least two-thirds of cases affect more than one joint during a first attack. Pseudogout may involve any joint, although the small joints in the fingers or toes are not commonly affected.
The symptoms of pseudogout also appear more slowly than those of gout, taking days rather than hours to develop.
Pseudogout is more likely to first develop in elderly people, particularly those with osteoarthritis.
Pseudogout is more likely to occur in the autumn while gout attacks are most common in the spring.
Who Gets Pseudogout?
Conditions that have a high risk of pseudogout in elderly patients include acute medical conditions, trauma, or surgery. Medical conditions linked to pseudogout include hypothyroidism, diabetes, gout, and osteoarthritis. Liver transplantation may also increase the risk.
How Is Pseudogout Treated?
There is no cure for pseudogout. It is a progressive disorder that can eventually destroy joints. Treatments for pseudogout are similar to those for gout and are aimed at relieving the pain and inflammation and reducing the frequency of attacks.
Nonsteroidal anti-inflammatory drugs (NSAIDs) are effective for treating inflammation and pain from pseudogout.
For acute attacks in large joints, fluid aspiration alone or with corticosteroids may help.
Colchicine may be used for acute attacks.
Magnesium carbonate may help dissolve crystals, but existing hard deposits may remain.
Surgery may be required for joint replacement.
Rheumatoid Arthritis. Rheumatoid arthritis can distort the joints of the finger and cause inflammation and pain that may be similar to gout. In older people, it is hard to tell chronic gout from rheumatoid arthritis. A proper diagnosis can be made with a detailed medical history, laboratory tests, and identification of MSU crystals.
Osteoarthritis. Gout can coincide and be confused with osteoarthritis in older people, particularly when it occurs in arthritic finger joints in women. In general, gout should be suspected if the joints in the fingertips are unusually enlarged.
Infections. Joint infections can have features that resemble gout. A correct diagnosis is important for proper treatment. A high fever and high white blood cell count help diagnose infection, while urate crystals in the joint usually point to gout.
Charcot Foot. People with diabetes who also have problems in the nerves in the feet (diabetic peripheral neuropathy) may develop Charcot foot or Charcot joint (medically known as neuropathic arthropathy). Early changes may resemble gout, with the foot becoming swollen, red, and warm, although it involves other parts of the foot other than the large toe.
Bunions. A bunion is a foot deformity that usually occurs at the joint at the base of the big toe. A bunion is actually a bony growth at the joint. It forms when the big toe is forced in toward the rest of the toes, causing the head of the first metatarsal bone to jut out and rub against the side of the shoe. The underlying tissue becomes inflamed, and a painful bump forms.
Treatment: Acute Gout Attack
Acute attacks of gout and long-term treatment of gout and hyperuricemia require different approaches. Treatment usually involves medication. After the first attack, some health care providers advise patients to keep a supply of medicines on hand to take at the first sign of symptoms of a second attack.
Treatments are prescribed for conditions associated with gout, including uric acid nephropathy and uric acid nephrolithiasis.
Supportive measures include applying ice and resting the affected joint.
Many patients do not require medication. Often lifestyle and dietary measures are enough to prevent attacks. Measures include not eating foods high in purines, not drinking alcohol, and maintaining a healthy weight.
Medicines for gout attacks are aimed at relieving pain and reducing inflammation. These include:
These medicines may be combined to treat a gout attack.
Nonsteroidal Anti-inflammatory Drugs (NSAIDs)
NSAIDs are the medicines of choice for an acute attack in younger, healthy patients with no serious health problems, such as of the kidneys, liver, or heart.
Many NSAIDs are available. Over-the-counter NSAIDs include ibuprofen, naproxen, ketoprofen.
Indomethacin is a prescription NSAID. It is often the first choice of treatment. Usually 2 to 7 days of high-dose indomethacin is enough to treat a gout attack.
Regular use of NSAIDs can cause health problems, such as ulcers and gastrointestinal bleeding. Patients should follow instructions exactly on how much to take and for how long to avoid such health problems.
Patients with diabetes who take hypoglycemics by mouth may need to adjust their dosage if they also take NSAIDs. This is because of possible harmful interactions between these medicines.
Colchicine is a derivative of the autumn crocus (meadow saffron). It has been used for gout attacks for centuries. It is very effective in relieving a gout attack. It should not be used by elderly patients or those with kidney, liver, or bone marrow disorders. Colchicine may affect fertility. This medicine should not be used during pregnancy.
Certain medicines can interact with colchicine such as some antibiotics and stomach acid reducers (H2 blockers).
Patients should tell their doctor about all other medicines they are taking before being prescribed colchicine.
Corticosteroids may be used in patients who cannot tolerate NSAIDs such as the elderly. Corticosteroid injections into an affected joint provide relief for many patients. Steroids taken by mouth may be used for patients who cannot take NSAIDs or colchicine and who have gout in more than one joint.
Medicine to Lower Blood Uric Acid Level
Persons already taking urate-lowering medicine will likely continue taking this medicine during an attack.
Treatment: Preventing Attacks
After an acute attack some patients remain at high risk of another attack for several weeks during the intercritical period. Such patients include those with kidney insufficiency or those with congestive heart failure who are on diuretics. Colchicine or NSAIDs may be used for 1 to 2 months or longer to prevent another attack.
Long-term Prevention of Attacks
Medicine that lowers uric acid level in the blood or that block uric acid production to prevent gout attacks and other complications is usually prescribed.
Hyperuricemia that causes no symptoms may not need to be treated with medicine. Asymptomatic hyperuricemia often does not lead to gout or other health problems.
Before treatment, a 24-hour urine collection sample may be ordered for patients with frequent gout attacks. This is to determine whether they are over-producers or under-excreters of uric acid.
Low doses of NSAIDs or colchicine are used during several months after introducing anti-hyperuricemic therapies to prevent gout attacks.
Long-term treatment of hyperuricemia may be recommended for people who have:
A risk for tophaceous gout
Had more than two or three acute attacks of gout in the past, particularly if the attacks have not responded promptly to treatment
Unusually severe attacks, or attacks that affect more than one joint
Joint damage from gout, as shown on x-rays
Uric acid kidney stones
Evidence of kidney damage due to elevated uric acid levels
Hyperuricemia caused by an identifiable inborn metabolic deficiency
An inability to use the medications used to treat acute gout
Uricosurics. These drugs prevent the kidney from reabsorbing uric acid, and therefore increase the amount excreted in the urine. They may be used when the kidneys are not eliminating (excreting) enough uric acid, which is present in about 80% of gout cases. The doctor will check a 24-hour urine to diagnose this problem. These medicines are not used for patients with reduced kidney function or those with tophaceous gout.
Other patients who may benefit from uricosurics include:
Those under 60 years of age
Those with normal diets
Those who have normal kidney function
Those who have no risk of kidney stones
NSAIDs, particularly aspirin and similar medicines, reduce the effectiveness of uricosurics. Patients taking uricosurics should avoid NSAIDs if possible.
Allopurinol. Allopurinol blocks uric acid production. It is the drug most often used in long-term gout treatment for older patients and those who overproduce uric acid.
When it is first used, allopurinol can trigger further attacks of gout. Therefore, during the first months or longer, the patient also takes an NSAID or colchicine to reduce that possibility.
Allopurinol has positive effects on "bad" cholesterol levels, so it may be better than other medicines for patients with both gout and coronary artery disease.
Precaution About Medicines for Gout
Some medicines for gout can precipitate (lead to) gout symptoms. Patients should work with their doctor to learn which medicines, combinations of medicines, and dosages may cause gout flare-ups.
People with gout have a high risk of high blood pressure (hypertension). Some medicines for hypertension, such as thiazide diuretics, can increase the risk of gout attacks. Other medicines, such as calcium channel blockers, may have beneficial effects on both high blood pressure and gout.
Surgery. Large tophi that are draining, infected, or interfering with the movement of joints may need to be surgically removed. Surgery may not be suitable for persons with other medical conditions such as infection. In such cases, measures such as taking medicines that lower uric acid could reduce the need for surgery.
Other types of surgeries are available to relieve joint pain and improve joint function. In some cases joint replacement is needed.
Rest and protecting the affected joint with a splint can also promote recovery. Applying ice packs and warmth can help relieve symptoms.
Uric acid level is only mildly affected by diet. Therefore, dietary therapy does not play a large role in preventing gout. Still, avoiding or reducing foods rich in purine can help.
Foods and drinks to avoid:
Organ meats (liver, kidney, heart, sweetbread)
High fructose corn syrup (in foods and drinks)
Alcohol during gout attacks
Foods and drinks to limit:
Beef, pork, lamb
Seafood rich in purine (shellfish, sardine, anchovy, tuna, herring)
Alcohol, especially beer and hard liquor
Eating a moderate amount of purine-rich vegetables (spinach, cauliflower, mushrooms, legumes) does not seem to increase the risk of gout.
Dairy products, especially low-fat products, may actually protect against gout. Drinking coffee may also have a preventive effect against gout. Taking folic acid and vitamin C may reduce uric acid level.
Drinking plenty of water helps remove uric acid from the body.
Alcohol, especially beer and hard liquor, raises uric acid level, which can lead to gout attacks. This is why so many persons who drink an excessive amount of alcohol have gout attacks. Drinking wine occasionally does not seem to be linked to an increase in gout attacks.
Fructose-rich diets, including soda and fruit juice, may increase the risk of gout.
Maintaining a Healthy Weight
A supervised weight-loss program may be effective in reducing uric acid level in overweight persons. Crash dieting, though, can have the opposite effect because it can increase uric acid level, causing an acute attack.
Medications to treat other conditions can increase uric acid level. For example, certain diuretics (water pills) and low dose daily aspirin can affect uric acid level. Switching to alternative treatments may be necessary.
Avoid Joint Injury
People with gout should avoid activities that cause repetitive joint trauma such as wearing tight shoes.
Preventing an Attack During Travel
Travel may increase the risk of gout attacks. Travel not only increases stress, but eating and drinking patterns may change. Before traveling, patients should discuss preventive measures with their health care provider. The doctor may prescribe taking a corticosteroid at the first sign of a gout attack. In most cases, this stops the attack.
Properly treated gout rarely poses a long-term health threat, though during an attack the pain can be disabling.
Pain and Disability
Left untreated, gout can develop into a painful and disabling chronic disorder. Persistent gout can destroy cartilage and bone. This causes deformed joints and loss of motion. If gout is not treated, tophi can grow to the size of golf balls and destroy bone and cartilage in the joints. This is similar to the process in rheumatoid arthritis. In very severe cases, joint destruction results in complete disability.
Kidney Stones. Kidney stones can occur after the development of hyperuricemia. Although the stones are usually made of uric acid, they may also be mixed with other materials.
Kidney Disease. Patients with chronic hyperuricemia may develop chronic kidney disease, which may lead to kidney failure. This is because a constant high level or uric acid can damage the kidneys.
Gout and Heart Disease
Gout is found in higher rates in people with high blood pressure, coronary artery disease, or heart failure. A high level of uric acid has been linked to a high risk of death from heart conditions. Studies have also found an association between gout and having metabolic syndrome. This is a collection of health problems, such as abdominal obesity, high blood pressure, high triglyceride levels, and low "good" cholesterol level. This syndrome increases a person's risk of heart disease and diabetes.
Click the icon to see an image of coronary artery blockage.
Other Medical Conditions Linked to Gout
Other conditions that are linked to long-term gout:
Dry eye syndrome
- Complications in the lungs (in rare cases, uric acid crystals occur in the lungs)
Burns CM, Wortmann RL. Clinical features and treatment of gout. In: Firestein GS, Budd RC, Gabriel SE, et al., eds. Kelley's Textbook of Rheumatology. 9th ed. Philadelphia, PA: Elsevier Saunders; 2012:chap 95.
Cameron M, Sakhaee K. Uric acid nephrolithiasis. Urol Clin N Am. 2007;34:335–346.
Choi HK, Ford ES, Li C, Curhan G. Prevalence of the metabolic syndrome in patients with gout: the Third National Health and Nutrition Examination Survey. Arthritis Rheum. 2007;57:109-15.
Choi HK, Willett W, Curhan G. Fructose-rich beverages and risk of gout in women. JAMA. 2010;304:2270-8.
Doherty M. New insights into the epidemiology of gout. Rheumotology. 2009;48:ii2-ii8.
Doghramji PP, Edwards NL, McTigue J. Managing gout in the primary care setting: what you and your patients need to know. Am J Med. 2010;123:S2.
Janssens HJ, Fransen J, van de Lisdonk EH, et al. A diagnostic rule for acute gouty arthritis in primary care without joint fluid analysis. Arch Intern Med. 2010;170:1120-6.
Keenan RT, Nowatzky J, Pillinger MH. Etiology and pathogenesis of hyperuracemia and gout. In: Firestein GS, Budd RC, Gabriel SE, et al., eds. Kelley's Textbook of Rheumatology. 9th ed. Philadelphia, PA: Elsevier Saunders; 2012:chap 94.
Khanna D, Fitzgerald JD, Khanna PP, et al. 2012 American College of Rheumatology Guidelines for Management of Gout. Part 1: Systematic Nonpharmacologic and Pharmacologic Therapeutic Approaches to Hyperurecemia. Arthrit Care Res. 2012;64:1431-1446.
Khanna D, Khanna PP, Fitzgerald JD, et al. 2012 American College of Rheumatology Guidelines for Management of Gout. Part 2: Therapy and Antiinflammatory Prophylaxis of Acute Gouty Arthritis. Arthrit Care Res. 2012;64:1447-1461.
Li S, Michelletti R. Role of diet in rheumatic disease. Rheum Dis Clin N Am. 2011;37:119–133.
Lebiedz-Odrobina D, Kay J. Rheumatic manifestations of diabetes mellitus. Rheum Dis Clin N Am. 2010;36:681–699.
Maynard JW, McAdams DeMarco MA, et al. Incident gout in women and association with obesity in the Atherosclerosis Risk in Communities (ARIC) study. Am J Med. e2012;125:717.e9-717.e17.
Neogi T. Clinical practice. Gout. N Engl J Med. 2011;364(5):443-52.
Nguyen S, Choi HK, Lustig RH, Hsu CY. Sugar-sweetened beverages, serum uric acid, and blood pressure in adolescents. J Pediatr. 2009;154:807-13.
Richette P, Bardin T. Gout. Lancet. 2010;375(9711):318-28.
Zhu YY, Pandya BJ, Choi HK. Comorbidities of gout and hyperuricemia in the US general population: NHANES 2007-2008. Am J Med. 2012;125:679-687.
- Last Reviewed on 04/05/2013
- Harvey Simon, MD, Editor-in-Chief, Associate Professor of Medicine, Harvard Medical School; Physician, Massachusetts General Hospital. Also reviewed by A.D.A.M. Health Solutions, Ebix, Inc., Editorial Team: David Zieve, MD, MHA, Bethanne Black, Stephanie Slon, and Nissi Wang.
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- 2013 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
This page was last updated: June 25, 2014