Sex-linked dominant

Toggle: English / Spanish

Definition

Sex-linked dominant is a rare way that a trait or disorder can be passed down through families. A single abnormal gene on the X chromosome can cause a sex-linked dominant disease.

Related terms and topics:

Alternative Names

Inheritance - sex-linked dominant; Genetics - sex-linked dominant; X-linked dominant; Y-linked dominant

Information

Inheritance of a specific disease, condition, or trait depends on the type of chromosome affected (autosomal or sex chromosome). It also depends on whether the trait is dominant or recessive. Sex-linked diseases are inherited through one of the sex chromosomes (the X or Y chromosome).

Dominant inheritance occurs when an abnormal gene from one parent is capable of causing disease, even though a matching gene from the other parent is normal. The abnormal gene dominates the gene pair.

For an X-linked dominant disorder: If the father carries the abnormal X gene, all of his daughters will inherit the disease and none of his sons will have the disease. That is because daughters always inherit their father's X chromosome. If the mother carries the abnormal X gene, half of all their children (daughters and sons) will inherit the disease tendency.

In other words, if there are four children (two males and two females) and the mother is affected (one abnormal X, she has the disease) but the father is not, the statistical expectation is for:

  • Two children (one girl and one boy) with the disease
  • Two children (one girl and one boy) without the disease

If there are four children (two males and two females) and the father is affected (abnormal X, he has the disease) but the mother is not, the statistical expectation is for:

  • Two girls with the disease
  • Two boys without the disease

This does not mean that the children will necessarily be affected.

References

Version Info

  • Last reviewed on 5/16/2012
  • Neil K. Kaneshiro, MD, MHA, Clinical Assistant Professor of Pediatrics, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org). URAC's accreditation program is an independent audit to verify that A.D.A.M. follows rigorous standards of quality and accountability. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.'s editorial policy, editorial process and privacy policy. A.D.A.M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health on the Net Foundation (www.hon.ch)

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- 2013 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

This page was last updated: April 14, 2014

         
Average rating (43)