Peripheral artery disease - legs
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Peripheral artery disease is a condition of the blood vessels that leads to narrowing and hardening of the arteries that supply the legs and feet.
The narrowing of the blood vessels leads to decreased blood flow, which can injure nerves and other tissues.
Peripheral vascular disease; PVD; PAD; Arteriosclerosis obliterans; Blockage of leg arteries; Claudication; Intermittent claudication; Vaso-occlusive disease of the legs; Arterial insufficiency of the legs; Recurrent leg pain and cramping; Calf pain with exercise
Causes, incidence, and risk factors
Peripheral artery disease is caused by arteriosclerosis, or "hardening of the arteries." This problem occurs when fatty material (plaque) builds up on the walls of your arteries. This causes the arteries to become narrower. The walls of the arteries also become stiffer and cannot widen (dilate) to allow greater blood flow when needed.
As a result, when the muscles of your legs are working harder (such as during exercise or walking) they cannot get enough blood and oxygen. Eventually, there may not be enough blood and oxygen, even when the muscles are resting.
Peripheral artery disease is a common disorder that usually affects men over age 50. People are at higher risk if they have a history of:
The classic symptoms are pain, achiness, fatigue, burning, or discomfort in the muscles of your feet, calves, or thighs. These symptoms usually appear during walking or exercise and go away after several minutes of rest.
At first, these symptoms may appear only when you walk uphill, walk faster, or walk for longer distances.
Slowly, these symptoms come on more quickly and with less exercise.
Your legs or feet may feel numb when you are at rest. The legs also may feel cool to the touch, and the skin may look pale.
When peripheral artery disease becomes severe, you may have:
Pain and cramps at night
Pain or tingling in the feet or toes, which can be so severe that even the weight of clothes or bed sheets is painful
Pain that is worse when you raise the leg and improves when you dangle your legs over the side of the bed
Skin that looks dark and blue
Sores that do not heal
Signs and tests
During an examination, the health care provider may find:
A whooshing sound with the stethoscope over the artery (arterial bruits)
Decreased blood pressure in the affected limb
Loss of hair on the legs or feet
Weak or absent pulses in the limb
When PAD is more severe, findings may include:
Calf muscles that shrink (wither or atrophy
Hair loss over the toes and feet
Painful, non-bleeding sores on the feet or toes (usually black) that are slow to heal
Paleness of the skin or blue color in the toes or foot (cyanosis
Shiny, tight skin
Blood tests may show high cholesterol or diabetes.
Tests for peripheral artery disease:
Balance exercise with rest. Walk or do another activity to the point of pain and alternate it with rest periods. Over time, your circulation may improve as new, small (collateral) blood vessels form. Always talk to the doctor before starting an exercise program.
Stop smoking. Smoking narrows the arteries, decreases the blood's ability to carry oxygen, and increases the risk of forming clots (
Take care of your feet, especially if you also have diabetes. Wear shoes that fit properly. Pay attention to any cuts, scrapes, or injuries, and see your doctor right away. Tissues heal slowly and are more likely to get infected when there is decreased circulation.
Make sure your blood pressure is well controlled.
Reduce your weight, if you are overweight.
Monitor your blood sugar levels if you have diabetes, and keep them under control.
Medications may be needed to control the disorder, including:
Aspirin or a medicine called clopidogrel (Plavix), which keeps your blood from forming clots in your arteries. Do NOT stop taking these medications without first talking with your doctor.
Cilostazol, a medication to enlarge (dilate) the affected artery or arteries for moderate-to-severe cases that are not candidates for surgery
Medicine to help lower your cholesterol
- Pain relievers
If you are taking medicines for high blood pressure or diabetes, take them as your doctor has prescribed.
Surgery may be performed if the condition is severe and is affecting your ability to work or do important activities, or you are having pain at rest. Options are:
Some people with peripheral artery disease may need to have the limb removed (amputated).
You can usually control peripheral artery disease of the legs without surgery. Surgery provides good symptom relief in severe cases.
For complications, the affected leg or foot may need to be amputated.
Calling your health care provider
Call your health care provider if you have:
A leg or foot that becomes cool to the touch, pale, blue, or numb
Chest pain or shortness of breath with leg pain
Leg pain that does not go away, even when you are not walking or moving (called rest pain)
Legs that are red, hot, or swollen
Symptoms of arteriosclerosis of the extremities
Mills JL. Lower extremity arterial disease. In: Cronenwett JL, Johnston W, eds. Rutherford's Vascular Surgery. 7th ed. Philadelphia, Pa: Saunders Elsevier; 2010:section 15.
Creager MA, Libby P. Peripheral arterial disease. In: Bonow RO, Mann DL, Zipes DP, Libby P, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 9th ed. Philadelphia, Pa: Saunders; 2011:chap 61.
Wong PF, Chong LY, Mikhailidis DP, Robless P, Stansby G. Antiplatelet agents for intermittent claudication. Cochrane Database Syst Rev. 2011. Issue 11. Art No.: CD001272. DOI: 10.1002/14651858.CD001272.pub2.
Watson L, Ellis B, Leng GC. Exercise for intermittent claudication. Cochrane Database Syst Rev. 2008. Issue 4. Art No.: CD000990. DOI: 10.1002/14651858.CD000990.pub2.
- Last reviewed on 5/14/2012
- Shabir Bhimji, MD, PhD, Specializing in Cardiothoracic and Vascular Surgery, Midland, TX. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M. Health Solutions, Ebix, Inc.
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