Immunoelectrophoresis - blood
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Serum immunoelectrophoresis is a lab test that measures proteins called immunoglobulins in the blood. There are many types of immunoglobulins. Some can be abnormal and due to cancer.
IEP - serum; Immunoglobulin electrophoresis - blood; Gamma globulin electrophoresis; Serum immunoglobulin electrophoresis
How the test is performed
A blood sample is needed. For information on how this is done, see: Venipuncture
How to prepare for the test
How the test will feel
When the needle is inserted to draw blood, you may feel moderate pain, or only a prick or stinging sensation. Afterward, there may be some throbbing.
Why the test is performed
This test is most often used to check the levels of certain immunoglobulins (or antibodies) associated with multiple myeloma and Waldenstrom's macroglobulinemia.
This test has mostly been replaced by another test calle immunofixation.
A normal (negative) result means no immunoglobulins were seen in the blood sample.
What abnormal results mean
Abnormal results may be due to certain types of cancer such as
Abnormal results may also be due to:
Some people have monoclonal immunoglobulins, but do not have cancer. This is called “monoclonal gammopathy of unknown significance," or MGUS.
What the risks are
- Excessive bleeding
- Fainting or feeling lightheaded
- Hematoma (blood accumulating under the skin)
- Infection (a slight risk any time the skin is broken)
Veins and arteries vary in size from one patient to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.
McPherson RA, Massey HD. Laboratory evaluation of immunoglobulin function and humoral immunity. In McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 22nd ed. Philadelphia,Pa: Saunders Elsevier; 2011:chap 46.
Perry MC. Plasma cell disorders. In Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, PA: Saunders Elsevier; 2011:chap193.
- Last reviewed on 6/5/2012
- David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
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