Fibrinolysis - primary or secondary

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Definition

Fibrinolysis is a normal body process that keeps naturally occurring blood clots from growing and causing problems.

Primary fibrinolysis refers to the normal breakdown of clots.

Secondary fibrinolysis is the breakdown of blood clots due to a medical disorder, medicine, or other cause. This may cause severe bleeding.

Alternative Names

Primary fibrinolysis; Secondary fibrinolysis

Causes, incidence, and risk factors

Blood clots form on a protein called fibrin. The breakdown of fibrin (fibrinolysis) can increase under certain conditions, such as:

  • Bacterial infections
  • Cancer
  • Intense exercise
  • Not enough oxygen to tissues

Sometimes, medicines may be given to help blood clots breakdown more quickly. For example, if a blood clot causes a heart attack.

Symptoms

Signs and tests

Treatment

Support Groups

Expectations (prognosis)

Complications

Calling your health care provider

Prevention

References

Schafer AI. Hemorrhagic disorders: Disseminated intravascular coagulation, liver failure, and vitamin K deficiency. In: Goldman L, Ausiello D, eds. Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 178.

Version Info

  • Last reviewed on 3/14/2012
  • David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M. Health Solutions, Ebix, Inc.

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This page was last updated: April 14, 2014

         
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