Toggle: English / Spanish
Drug-induced hypoglycemia is low blood sugar that results from medication.
Low blood sugar is common in people with diabetes who are taking insulin or other medicines to control their diabetes.
All of the following can cause blood sugar (glucose) levels to drop:
Even when diabetes is managed very carefully, the medications used to treat diabetes can result in drug-induced hypoglycemia. The condition may also occur when someone without diabetes takes a medicine used to treat diabetes. In rare cases, non-diabetes-related medicines may cause hypoglycemia.
Medications that can cause drug-induced hypoglycemia include:
Bactrim (an antibiotic)
Metformin when used with sulfonylureas
SGLT2 inhibitors (such as dapagliflozin and empagliflozin)
Thiazolidinediones (such as Actos and Avandia)
Cryer PE. Glycemic goals in diabetes: Trade-off between glycemic control and iatrogenic hypoglycemia. Diabetes. 2014;63:2188-2195.
Cryer PE. Hypoglycemia. In: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, eds. Williams Textbook of Endocrinology. 12th ed. Philadelphia, PA: Elsevier Saunders; 2011:chap 34.
Inzucchi SE, Sherwin RS. Type 1 diabetes mellitus. In: Goldman L, Schafer AI, eds. Goldman's Cecil Textbook of Medicine. 24th ed. Philadelphia, PA: Elsevier Saunders; 2011:chap 236.
- Last reviewed on 11/25/2014
- Robert Hurd MD, Professor of Endocrinology and Bioethics at Xavier University, Cincinnati, Ohio. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- 2013 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
This page was last updated: May 4, 2015