Toggle: English / Spanish
The Bernstein test is a method to reproduce symptoms of heartburn. It is usually done with other tests to measure esophageal function.
Acid perfusion test
How the test is performed
The test is done in a gastroenterology laboratory. A nasogastric (NG) tube is through one side of your nose and into your esophagus. Mild hydrochloric acid will be sent down the tube, followed by salt water (saline) solution. This process may be repeated several times.
You will be asked to tell the health care team about any pain or discomfort you have during the test.
How to prepare for the test
You should not eat or drink anything for 8 hours before the test.
How the test will feel
You may have a gagging feeling and some discomfort when the tube is put into place. The acid may cause symptoms of heartburn. Your throat may be sore after the test.
Why the test is performed
The test tries to reproduce symptoms of gastroesophageal reflux (stomach acids coming back up into the esophagus). It is done to see if you have the condition.
The test results will be negative.
What abnormal results mean
A positive test shows that tyour symptoms are caused by esophageal reflux of acid from the stomach.
What the risks are
There is a risk of gagging or vomiting.
Fass R. Evaluation and diagnosis of noncardiac chest pain. Dis Mon. 2008;54:627-641.
Kahrilas PJ, Pandolfino JE. Esophageal neuromuscular function and motility disorders. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 9th ed. Philadelphia, Pa: Saunders Elsevier; 2010:chap 42.
- Last Reviewed on 10/08/2012
- George F. Longstreth, MD, Department of Gastroenterology, Kaiser Permanente Medical Care Program, San Diego, California. Also reviewed by A.D.A.M. Health Solutions, Ebix, Inc., Editorial Team: David Zieve, MD, MHA, David R. Eltz, and Stephanie Slon.
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- 2013 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
This page was last updated: May 31, 2013