Zolmitriptan (Into the nose)
Treats migraine headaches in adults.
There may be other brand names for this medicine.
When This Medicine Should Not Be Used
You should not use this medicine if you have had an allergic reaction to zolmitriptan, or if you have a history of heart disease, stroke, ischemic bowel disease, or peripheral vascular disease. You should not use this medicine if you have uncontrolled high blood pressure, or hemiplegic or basilar migraine headaches. Do not use this medicine if you have used any other migraine medicines such as sumatriptan (Imitrex®) or sumatriptan/naproxen (Treximet®) in the past 24 hours. Do not use this medicine if you have used an ergotamine medicine (such as methysergide, or D.H.E. 45®) within the past 24 hours. You should not use this medicine if you have used an MAO inhibitor (MAOI) such as Eldepryl®, Marplan®, Nardil®, or Parnate® within the past 14 days.
How to Use This Medicine
- Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
- This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.
- This medicine is for use only in the nose. Do not get any of it in your eyes or on your skin. If it does get on these areas, rinse it off right away.
- This medicine relieves migraine headaches, but will not prevent a migraine. You should only use zolmitriptan when you actually have a migraine.
- Usually, one dose of this medicine will decrease or take away your migraine headache. If you have a second headache at least 2 hours after using this medicine, you may use a second dose. There is a maximum amount of this medicine that is safe to use in one day. If one dose does not decrease or take away your headache, talk with your doctor before using more medicine.
If a dose is missed:
- Zolmitriptan is only used when you have a migraine. It is not used on a regular schedule.
How to Store and Dispose of This Medicine
- Keep the bottle tightly closed when not using it. Store at room temperature, away from heat and direct light.
- Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
- Keep all medicine away from children and never share your medicine with anyone.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you are using birth control pills, cimetidine (Tagamet®), propranolol (Inderal®), or a medicine for depression (such as fluoxetine, fluvoxamine, paroxetine, sertraline, Luvox®, Paxil®, Prozac®, or Zoloft®).
Warnings While Using This Medicine
- Make sure your doctor knows if you are pregnant, if you plan to become pregnant, or if you are breastfeeding. Tell your doctor if you have liver disease.
- If you are at higher risk for heart disease, talk with your doctor before using this medicine. Risk factors for heart disease include smoking, high cholesterol, a family history of heart disease, being overweight, and having diabetes. Men over the age of 40 and postmenopausal women are also at risk of heart disease.
- You should not use zolmitriptan if your headache symptoms are different from the symptoms you usually have with a migraine headache. If you have a severe headache and do not know the cause, call your doctor.
- This medicine may cause a serious condition called serotonin syndrome when taken with certain medicines. Check with your doctor first before taking any other medicines.
- This medicine may make you dizzy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
Possible Side Effects While Using This Medicine
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Chest, neck, or jaw pain or tightness.
- Fast or uneven heartbeat.
- Numbness or tingling in your hands, arms, legs, or feet.
- Stomach pain, diarrhea, or blood in your stools.
If you notice these less serious side effects, talk with your doctor:
- Bad or unusual taste in your mouth, or dry mouth.
- Burning, numbness, tingling, or pain in your nose.
- Feeling dizzy, drowsy, weak, or tired.
- Feeling of heat, tingling, heaviness, or pressure.
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
- Last Reviewed on 06/12/2013
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This page was last updated: September 18, 2013