Trimethobenzamide (Rectal)

Introduction

Benzocaine (BEN-zoe-kane), Trimethobenzamide (trye-meth-oh-BENZ-a-mide)

Treats nausea and vomiting. This medicine was withdrawn from the U.S. market on April 6, 2007, because it has not been found to be effective.

Brand Name(s)

Navogan

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

You should not use this medicine if you have had an allergic reaction to trimethobenzamide or to local anesthetics like novocaine or xylocaine. This medicine should not be given to children unless approved by your doctor.

How to Use This Medicine

Suppository

  • Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
  • Never take rectal suppositories by mouth.
  • Drink plenty of fluids while you are using this medicine to keep from getting dehydrated.
  • Wash your hands with soap and water before and after using this medicine. Remove the foil or wrapper from the suppository before inserting it.
  • To make the suppository easier to insert, you may use a lubricating gel such as K-Y® Jelly, but do not use petroleum jelly (Vaseline®).
  • Lie on your left side with your left leg straight or slightly bent, and your right knee bent upward. Gently push the pointed end of the suppository into the rectum about 1 inch.
  • Keep lying down for about 15 minutes to keep the suppository from coming out before it melts. Then, wash your hands again.

If a dose is missed:

  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • You may store the suppositories in the refrigerator, but do not freeze them.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of the used medicine applicator(s), containers, and any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Tell your doctor if you are using any medicines that make you sleepy. These include sleeping pills, cold and allergy medicine, narcotic pain relievers, and sedatives.
  • Do not drink alcohol while you are using this medicine.

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding.
  • This medicine may make you drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
  • If your vomiting does not stop after taking this medicine for one day, call your doctor.
  • If your doctor has instructed you to give this medicine to a child, watch carefully for side effects such as vomiting, drowsiness, or unusual behavior. If your child has any of these signs, stop using the medicine and call your doctor right away.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
  • Dark-colored urine or pale stools.
  • Hot, dry skin without sweating.
  • Lightheadedness or fainting.
  • Problems with balance or walking.
  • Seizures.
  • Uncontrollable muscle movements or twitching.
  • Unusual bleeding, bruising, or weakness.
  • Yellow skin or eyes.

If you notice these less serious side effects, talk with your doctor:

  • Blurred vision.
  • Headache.
  • Mild diarrhea.
  • Muscle cramps.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last Reviewed on 06/12/2013

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This page was last updated: June 18, 2013

         
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