Trazodone (By mouth)
Treats depression. This medicine is an antidepressant.
Desyrel Dividose, Desyrel, Trazamine, Oleptro
There may be other brand names for this medicine.
When This Medicine Should Not Be Used
Do not use this medicine if you have had an allergic reaction to trazodone. Do not use this medicine if you currently use an MAO inhibitor (MAOI) such as Eldepryl®, linezolid (Zyvox®), Marplan®, methylene blue, Nardil®, or Parnate® or have used an MAOI in the past 14 days.
How to Use This Medicine
Tablet, Long Acting Tablet
- Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.
- Take the regular tablet with or shortly after a meal or light snack.
- Take the extended-release tablet at the same time each day, preferably at bedtime, without food.
- The tablet can be swallowed whole, or you may break the tablet in half along the score line. Do not break the tablet unless your doctor tells you to. Do not crush or chew the tablet.
- This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the Medication Guide if you do not have one.
If a dose is missed:
- If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
- Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
- Keep all medicine away from children and never share your medicine with anyone.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you also use carbamazepine (Tegretol®), digoxin (Lanoxin®), phenytoin (Dilantin®), medicine for HIV or AIDS (such as indinavir, ritonavir, Crixivan®, Norvir®), medicine to treat a fungal infection (such as fluconazole, itraconazole, ketoconazole, Diflucan®, Nizoral®), a diuretic (water pill, such as furosemide, hydrochlorothiazide, Lasix®), blood pressure medicine (such as atenolol, lisinopril, metoprolol, Accupril®, Cozaar®, Diovan®, Lotrel®, Norvasc®, Zestril®), an NSAID pain or arthritis medicine (such as aspirin, diclofenac, ibuprofen, naproxen, Advil®, Aleve®, Celebrex®, Voltaren®), or a blood thinner (such as warfarin, Coumadin®, Jantoven®).
- Make sure your doctor knows if you use buspirone (Buspar®), fentanyl (Abstral®, Duragesic®), lithium (Eskalith®, Lithobid®), tryptophan, St John's wort, other medicines for depression (such as amitriptyline, doxepin, fluoxetine, nefazodone, nortriptyline, paroxetine, Celexa®, Effexor®, Elavil®, Lexapro®, Pamelor®, Paxil®, Prozac®, Sarafem®, Sinequan®, Vivactil®, Zoloft®), or pain or migraine medicines (such as sumatriptan, tramadol, Frova®, Maxalt®, Relpax®, Zomig®).
- Tell your doctor if you also use arsenic trioxide (Trisenox®), cisapride (Propulsid®), dofetilide (Tikosyn®), certain antibiotics (such as erythromycin, levofloxacin, moxifloxacin, sparfloxacin, Avelox®, Levaquin®, Zagam®), or medicine to treat mental illness (such as haloperidol, mesoridazine, pimozide, prochlorperazine, quetiapine, thioridazine, ziprasidone, Compazine®, Geodon®, Haldol®, Mellaril®, Orap®, Serentil®, Seroquel®).
- Tell your doctor if you are using any medicines that make you sleepy. These include sleeping pills, cold and allergy medicine, narcotic pain relievers, and sedatives.
Warnings While Using This Medicine
- Make sure your doctor knows if you are pregnant or breastfeeding or if you have kidney disease, liver disease, bleeding problems, heart disease, heart rhythm problems, low blood pressure, or mineral imbalance (such as low magnesium, potassium, or sodium in the blood). Tell your doctor if you recently had a heart attack or have had priapism (a prolonged painful erection).
- For some children, teenagers, and young adults, this medicine can increase thoughts of suicide. Tell your doctor right away if you start to feel more depressed and have thoughts about hurting yourself. Report any unusual thoughts or behaviors that trouble you, especially if they are new or are getting worse quickly. Let the doctor know if you or anyone in your family has bipolar disorder (manic-depressive) or has tried to commit suicide.
- Check with your doctor right away if you have anxiety, restlessness, a fast heartbeat, fever, sweating, muscle spasms, nausea, vomiting, diarrhea, or see or hear things that are not there. These may be symptoms of a serious condition called serotonin syndrome. Your risk may be higher if you also take other medicines that affect serotonin levels in your body.
- Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation.
- Alcohol, narcotic pain relievers, or sleeping pills may cause you to feel more lightheaded, dizzy, or faint when used with this medicine. Tell your doctor if you drink alcohol or use pain relievers or sleeping pills.
- Dizziness, lightheadedness, or fainting may occur, especially when you get up suddenly from a lying or sitting position. Stand or sit up slowly if you are dizzy. Check with your doctor if this problem continues or gets worse.
- Do not stop using this medicine suddenly without asking your doctor. You may need to slowly decrease your dose before stopping it completely.
- This medicine may make you dizzy or drowsy. Do not drive, use machines, or do anything else that could be dangerous until you know how this medicine affects you.
- Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before you have surgery.
- Your doctor will need to check your progress at regular visits while you are using this medicine. Be sure to keep all appointments.
Possible Side Effects While Using This Medicine
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Anxiety, restlessness, fever, sweating, muscle spasms, nausea, vomiting, diarrhea, seeing or hearing things that are not there
- Confusion, weakness, unsteadiness
- Fast, pounding, or uneven heartbeat
- Feeling irritable, trouble sleeping
- Lightheadedness, dizziness, fainting
- Painful, prolonged erection of your penis
- Unusual behavior, thoughts of hurting yourself or others
- Unusual bleeding or bruising
If you notice these less serious side effects, talk with your doctor:
- Blurred vision or changes in vision
- Constipation, mild nausea
- Dry mouth
- Sleepiness or unusual drowsiness
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
- Last Reviewed on 06/12/2013
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This page was last updated: June 18, 2013