Teriflunomide (By mouth)

Introduction

Teriflunomide (ter-i-FLOO-noe-mide)

Treats multiple sclerosis.

Brand Name(s)

Aubagio

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

Do not use this medicine if you have had an allergic reaction to teriflunomide, or if you are pregnant. Do not use this medicine if you also use leflunomide (Arava®) or if you have severe liver disease.

How to Use This Medicine

Tablet

  • Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
  • Teriflunomide may stay in your blood for up to 2 years after you stop using it. Your doctor can give you medicine to remove it from your body much faster, if needed. Talk to your doctor if you have questions about this.
  • This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the Medication Guide if you do not have one.

If a dose is missed:

  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you also use alosetron (Lotronex®), cholestyramine (Questran®), duloxetine (Cymbalta®), paclitaxel (Taxol®), pioglitazone (Actos®), repaglinide (Prandin®), rosiglitazone (Avandia®), theophylline (Theo-Dur®), tizanidine (Zanaflex®), birth control pills (such as ethinyl estradiol, levonorgestrel, Estinyl®), or a blood thinner (such as warfarin, Coumadin®, Jantoven®).
  • Tell your doctor if you are receiving a treatment or using a medicine that causes a weak immune system, such as cancer medicines.
  • Talk to your doctor before getting flu shots or other vaccines. You should not receive live virus vaccines while you take this medicine.

Warnings While Using This Medicine

  • Using this medicine while you are pregnant can harm your unborn baby. The medicine may also cause birth defects if the father is using it when his sexual partner becomes pregnant. If a pregnancy occurs while you are using this medicine, tell your doctor right away.Use an effective form of birth control to prevent pregnancy.
  • Make sure your doctor knows if you are breastfeeding or if you have kidney disease, liver disease, bone marrow problems, diabetes, high blood pressure, high potassium in the blood, lung disease, nerve problems, a weak immune system, or any type of infection.
  • Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. These could be symptoms of a serious liver problem.
  • This medicine lowers the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily. To help with these problems, avoid being near people who are sick or have infections. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.
  • You will need to have a skin test for tuberculosis before you start to use this medicine. Tell your doctor if you develop any symptoms of infection, such as fever, chills, body aches, nausea, or vomiting.
  • Check with your doctor right away if you have burning, numbness, tingling, or painful sensations in the arms, hands, legs, or feet. These could be symptoms of a condition called peripheral neuropathy.
  • Serious skin reactions can occur. Check with your doctor right away if you have blistering, peeling, or loose skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills.
  • This medicine could make existing lung disease worse or cause new symptoms. Check with your doctor right away if you have trouble breathing and a cough.
  • You will need to have your blood pressure measured before you start using this medicine and while you are using it. If you notice any change to your recommended blood pressure, call your doctor right away.
  • Your doctor will need to check your blood or urine at regular visits while you are using this medicine. Be sure to keep all appointments.
  • Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain medical tests.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Confusion, weakness, uneven heartbeat, trouble breathing
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, pain in your upper stomach, yellow skin or eyes
  • Decrease in how much or how often you urinate, pain in your side
  • Fast, slow, or pounding heartbeat
  • Fever, chills, cough, runny or stuffy nose, sore throat, and body aches
  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet
  • Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

  • Diarrhea
  • Hair loss

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last Reviewed on 06/12/2013

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This page was last updated: June 18, 2013

         
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