Sodium phenylbutyrate (By mouth)

Introduction

Sodium Phenylbutyrate (SOE-dee-um fen-il-BUE-ti-rate)

Treats urea cycle disorders to help remove nitrogen from the body.

Brand Name(s)

Buphenyl, SPB11

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

You should not use this medicine if you or your child have had an allergic reaction to sodium phenylbutyrate.

How to Use This Medicine

Powder, Tablet, Coated Tablet

  • Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
  • It is best to take this medicine with food or milk.
  • If you are using the oral powder, you can mix it with water or food (solid or liquid). Powder mixed with food should be used right away. Powder mixed in water can be stored for up to one week at room temperature or in the refrigerator.
  • Carefully follow your doctor's instructions about any special diet.

If a dose is missed:

  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are using probenecid (Benemid®) or steroids (such as dexamethasone, prednisolone, prednisone, Celestone®, Cortone®, Decadron®, Deltasone®, or Pediapred®). Tell your doctor if you are also using haloperidol (Haldol®) or valproic acid (Depakene®).

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have heart disease, kidney disease, liver disease, or edema (swelling from excess fluid).
  • Your doctor will need to check your blood at regular visits while you are using this medicine. Be sure to keep all appointments.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Decrease in how much or how often you urinate.
  • Heart rhythm problems.
  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet.
  • Severe menstrual bleeding.
  • Severe vomiting or rectal bleeding.
  • Sudden or severe stomach pain, nausea, vomiting, fever, or lightheadedness.
  • Swelling in your hand, ankles, or feet.
  • Unusual bleeding, bruising, or weakness.

If you notice these less serious side effects, talk with your doctor:

  • Change in monthly periods.
  • Depression.
  • Headache or weight gain.
  • Nausea or mild stomach pain.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last Reviewed on 06/12/2013

A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org). URAC's accreditation program is an independent audit to verify that A.D.A.M. follows rigorous standards of quality and accountability. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.'s editorial policy, editorial process and privacy policy. A.D.A.M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health on the Net Foundation (www.hon.ch)

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- 2013 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.

This page was last updated: June 18, 2013

         
Average rating (0)