Ruxolitinib (By mouth)

Introduction

Ruxolitinib (rux-oh-LI-ti-nib)

Treats a blood or bone marrow problem called myelofibrosis.

Brand Name(s)

Jakafi

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

You should not use this medicine if you have had an allergic reaction to ruxolitinib.

How to Use This Medicine

Tablet

  • Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.
  • If you cannot swallow the tablets, tell your doctor right away. Your doctor will decide if you can take this medicine through a nasogastric tube. Your doctor will give you instructions on how to take this medicine through a tube.
  • If you receive a dialysis treatment, this medicine should be taken after the treatment.
  • This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.

If a dose is missed:

  • If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not take extra medicine.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using conivaptan (Vaprisol®) or nefazodone (Serzone®).
  • Make sure your doctor knows if you are also using medicine to treat hepatitis C infection (boceprevir, telaprevir, Victrelis®, Incivek®), medicine to treat a bacterial infection (such as clarithromycin, telithromycin, Biaxin®, or Ketek®), medicine to treat HIV or AIDS (such as indinavir, lopinavir/ritonavir, nelfinavir, ritonavir, saquinavir, Crixivan®, Fortovase®, Invirase®, Kaletra®, Norvir®, or Viracept®), or medicine to treat a fungus infection (such as itraconazole, ketoconazole, posaconazole, voriconazole, Nizoral®, Sporanox®, or Vfend®).
  • Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, or anemia. Tell your doctor if you are on dialysis.
  • This medicine lowers the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily. To help with these problems, avoid being near people who are sick or have infections. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.
  • Tell your doctor if you have any kind of infection before you start using this medicine. Also tell your doctor if you have had an infection that would not go away or an infection that kept coming back.
  • Check with your doctor right away if you have a painful or burning skin rash or blisters. These may be symptoms of herpes zoster (shingles).
  • Do not stop using this medicine suddenly without asking your doctor. You may need to slowly decrease your dose before stopping it completely.
  • If your condition does not improve within 6 months, or if it becomes worse, check with your doctor.
  • Your doctor will need to check your blood at regular visits while you are using this medicine. Be sure to keep all appointments.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Decrease in how much or how often you urinate, or painful urination
  • Fever, chills, cough, sore throat, and body aches
  • Painful or burning skin rash or blisters
  • Trouble breathing
  • Tiny red dots on the skin
  • Unusual bleeding or bruising
  • Unusual tiredness or weakness

If you notice these less serious side effects, talk with your doctor:

  • Headache or dizziness
  • Weight gain

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last Reviewed on 06/12/2013

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This page was last updated: June 18, 2013

         
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