Rabeprazole (By mouth)

Introduction

Rabeprazole (ra-BEP-ra-zole)

Treats heartburn, stomach ulcers, gastroesophageal reflux disease (GERD), esophagus damage, and conditions that cause your stomach to make too much acid, such as Zollinger-Ellison syndrome. This medicine may be used in combination with antibiotics to treat H pylori stomach infections and ulcers. This medicine is a proton pump inhibitor (PPI).

Brand Name(s)

Aciphex

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

Do not use this medicine if you have had an allergic reaction to rabeprazole or similar medicines, such as lansoprazole, omeprazole, pantoprazole, Nexium®, Prevacid®, or Protonix®. If you are using this medicine with clarithromycin, do not use these medicines together with cisapride (Propulsid®) or pimozide (Orap®).

How to Use This Medicine

Delayed Release Tablet

  • Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
  • Swallow the tablet whole with water. Do not chew, crush, or break it.
  • This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.

If a dose is missed:

  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using cyclosporine (Gengraf®, Neoral®, Sandimmune®), digoxin (Lanoxin®), ketoconazole (Nizoral®), methotrexate (Rheumatrex®, Trexall®), an iron supplement, or a blood thinner (such as warfarin, Coumadin®, Jantoven®).
  • Do not take atazanavir (Reyataz®) with this medicine, unless your doctor says it is okay.
  • Tell your doctor if you are also using a diuretic (water pill, such as furosemide, hydrochlorothiazide (HCTZ), indapamide, metolazone, torsemide, Demadex®, Lasix®, or Zaroxolyn®).

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have liver problems, osteoporosis, or a history of low magnesium levels in your blood.
  • This medicine may cause hypomagnesemia (low magnesium in the blood). This is more likely to occur if you take this medicine longer than 1 year, or if you take it with digoxin or certain diuretics (water pills). Tell your doctor right away if you have seizures, dizziness, a fast or pounding heartbeat, or muscle spasms.
  • You may be at risk for Clostridium difficile colitis (also called C diff) if you take this medicine. C diff is an inflammation of your large intestine that causes diarrhea. You have a higher risk of this condition if you are also using an antibiotic, are elderly, or have other chronic conditions.If you have severe diarrhea, ask your doctor before taking any medicine to stop the diarrhea.
  • This medicine may increase your risk of broken bones in the hip, wrist, or spine. This is more likely if you are older than 50, if you take this medicine more than once a day, or if you use it for 1 year or longer.
  • This medicine is sometimes given together with other medicines to treat ulcers. Make sure you understand how to use the combination of medicines.
  • Your doctor will need to check your progress at regular visits while you are using this medicine. Be sure to keep all appointments.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Dizziness
  • Fast, pounding, or uneven heartbeat
  • Muscle spasms, cramps
  • Seizures
  • Severe diarrhea that does not go away, stomach pain, and fever

If you notice these less serious side effects, talk with your doctor:

  • Headache
  • Mild diarrhea, gas

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last Reviewed on 06/12/2013

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This page was last updated: June 18, 2013

         
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