Quinapril/hydrochlorothiazide (By mouth)

Introduction

Hydrochlorothiazide (hye-droe-klor-oh-THYE-a-zide), Quinapril Hydrochloride (KWIN-a-pril hye-droe-KLOR-ide)

Treats high blood pressure. A lower blood pressure can reduce the risk of stroke and heart attack. This medicine is a combination of an angiotensin-converting enzyme (ACE) inhibitor and a diuretic (water pill).

Brand Name(s)

Accuretic

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

Do not use this medicine if you have had an allergic reaction to quinapril, hydrochlorothiazide, or a sulfa drug. Do not use this medicine if you are pregnant, if you are not able to urinate, or if you have a history of angioedema (swelling of the face, arms, legs, or throat) caused by an ACE inhibitor. Do not use this medicine together with aliskiren (Tekturna®) if you have diabetes.

How to Use This Medicine

Tablet

  • Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.
  • Carefully follow your doctor's instructions about any special diet.Be sure to drink plenty of fluids, especially if you exercise, sweat more than usual, or have diarrhea or vomiting.

If a dose is missed:

  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you also use aliskiren (Tekturna®), lithium (Eskalith®, Lithobid®), norepinephrine, tetracycline (Sumycin®), gold injections (such as sodium aurothiomalate), or another diuretic (water pill, such as amiloride, spironolactone, triamterene, Aldactone®). Tell your doctor if you also use a diabetes medicine (insulin or oral medicine such as glimepiride, glyburide, metformin, Actos®, Janumet®, Januvia®), medicine to lower cholesterol (such as cholestyramine, colesevelam, colestipol, Questran®, Welchol®), an NSAID pain or arthritis medicine (such as aspirin, diclofenac, ibuprofen, naproxen, Advil®, Aleve®, Celebrex®, Voltaren®), a steroid medicine (such as hydrocortisone, methylprednisolone, prednisolone, prednisone), or other blood pressure medicines.
  • Ask your doctor before you use any medicine, supplement, or salt substitute that contains potassium.
  • Alcohol, narcotic pain relievers, or sleeping pills may cause you to feel more lightheaded, dizzy, or faint when used with this medicine.

Warnings While Using This Medicine

  • Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.
  • Make sure your doctor knows if you are breastfeeding, or if you have kidney disease, liver disease, heart or blood vessel disease, congestive heart failure, high cholesterol, low blood pressure, or a mineral imbalance (such as high or low calcium, magnesium, potassium, or sodium in the blood). Tell your doctor if you have diabetes, glaucoma, gout, or a collagen vascular disease (such as lupus or scleroderma).
  • Call your doctor right away if you have severe stomach pain (with or without nausea or vomiting). This could be a symptom of intestinal angioedema.
  • This medicine could lower your blood pressure too much and cause you to feel dizzy or lightheaded. Stand or sit up slowly if you are dizzy. This is more likely to happen when you begin to use the medicine.
  • This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous until you know how this medicine affects you.
  • Stop using this medicine and check with your doctor right away if you have upper stomach pain, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. These could be symptoms of a serious liver problem.
  • Check with your doctor if you have a fever, chills, or sore throat. These could be symptoms of an infection caused by low white blood cell counts.
  • Check with your doctor immediately if you have eye pain, trouble seeing, or any vision changes.
  • Make sure any doctor or dentist who treats you knows that you are using this medicine.
  • This medicine may be less effective in black patients.
  • Angioedema and other allergic reactions are rare, but are more common among black patients.
  • Do not stop using this medicine without asking your doctor, even if you feel well. This medicine will not cure your high blood pressure, but it will help lower it and keep it down. You may have to take blood pressure medicine for the rest of your life.
  • Your doctor will need to check your blood or urine at regular visits while you are using this medicine. Be sure to keep all appointments.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blurred vision or changes in vision
  • Change in how much or how often you urinate, problems urinating
  • Confusion, weakness, uneven heartbeat, trouble breathing, numbness or tingling in your hands, feet, or lips
  • Dark urine or pale stools, yellow skin or eyes
  • Dry mouth, increased thirst, muscle cramps, nausea, vomiting
  • Fast, slow, or pounding heartbeat
  • Fever, chills, sore throat, and body aches
  • Lightheadedness, dizziness, fainting
  • Severe stomach pain (with or without nausea or vomiting)

If you notice these less serious side effects, talk with your doctor:

  • Dry cough

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last Reviewed on 06/12/2013

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This page was last updated: June 18, 2013

         
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