Progesterone (Injection)


Progesterone (proe-JES-ter-one)

Treats menstruation problems caused by a hormone imbalance.

Brand Name(s)

When This Medicine Should Not Be Used

How to Use This Medicine


  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot into one of your muscles.
  • This medicine is usually given every day for 6 to 8 days, depending on the reason you need it.
  • Missed dose: You must use this medicine on a fixed schedule. Call your doctor or pharmacist if you miss a dose.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine

  • Tell your doctor if you are pregnant or breastfeeding, or if you have diabetes, heart disease, migraine headaches, epilepsy, asthma, kidney disease, or a history of depression.
  • This medicine may cause blood clots, which may lead to serious problems such as stroke, embolism, or thrombosis.
  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.
  • This medicine may make you sleepy, tired, or dizzy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Chest pain, trouble breathing, or coughing up blood
  • Depression
  • Numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking
  • Rapid weight gain, swelling in your hands, ankles, or feet
  • Unusual, heavy, or nonstop vaginal bleeding

If you notice these less serious side effects, talk with your doctor:

  • Breast pain or tenderness
  • Light breakthrough bleeding or spotting
  • Pain, swelling, or redness where the shot was given

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last reviewed on 7/4/2015

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