Prochlorperazine (By mouth)

Introduction

Prochlorperazine (proe-klor-PER-a-zeen)

Treats nausea and vomiting. It has also been used for emotional disorders. Belongs to a class of drugs called phenothiazines.

Brand Name(s)

Compazine

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

You should not use this medicine if you have had an allergic reaction to any phenothiazine drug (such as Mellaril®, Prolixin®, Stelazine®, Thorazine®, or Trilafon®).

How to Use This Medicine

Tablet, Long Acting Capsule, Liquid

  • Your doctor will tell you how much medicine to take and how often.
  • May take with or without food.
  • Swallow the extended-release capsule whole. Do not crush or chew.
  • Do not get the oral liquid on your skin.

If a dose is missed:

  • If you take several doses a day, take the missed dose if it is within one hour of the missed dose, otherwise skip the missed dose and continue with your regular dosing schedule.
  • If you take one dose a day, take the missed dose as soon as possible. If it is almost time for your next regular dose, skip the missed dose.
  • You should not use two doses at the same time.

How to Store and Dispose of This Medicine

  • Store at room temperature, away from heat, light, and moisture.
  • Keep all medicine out of the reach of children.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not drink alcohol while using this medicine.
  • You should not use at the same time as antacids such as Mylanta®, Maalox®, or Amphojel®.
  • Avoid using drugs that can make you sleepy such as sleeping pills, sedatives, tranquilizers, antihistamines, or narcotic pain killers.

Warnings While Using This Medicine

  • If you are pregnant or breastfeeding, talk to your doctor before using this medicine.
  • Talk with your doctor before using if you have a seizure disorder, heart, liver, or lung disease, or any other medical problem.
  • This medicine may cause drowsiness. If it does, avoid driving a car or operating machinery.
  • Stand up slowly after you have been sitting or lying down to decrease dizziness.
  • This medicine may make your skin more sensitive to the sun. Try not to spend long periods in direct sunlight and protect your skin from the sun.
  • Prochlorperazine may cause a false reading of some types of pregnancy tests.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Trouble going to the bathroom (urinating)
  • Skin rash
  • Rapid breathing or heartbeat
  • Convulsions (seizures)
  • Spasms of neck, face or back
  • Muscle twitching or jerking
  • Unexplained fever, severe muscle stiffness

If you notice these less serious side effects, talk with your doctor:

  • Drowsiness or dizziness
  • Dry mouth
  • Nausea
  • Changes in vision such as difficulty focusing
  • Constipation

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last Reviewed on 06/12/2013

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This page was last updated: June 18, 2013

         
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