Probenecid/colchicine (By mouth)


Colchicine (KOL-chi-seen), Probenecid (proe-BEN-e-sid)

Treats gouty arthritis and severe attacks of gout.

Brand Name(s)

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

You should not use this medicine if you have ever had an allergic reaction to probenecid or colchicine, or if you are pregnant. You should not use aspirin while taking this medicine. Tell your doctor if you have ever had ulcers, kidney problems (including kidney stones), or blood disorders.

How to Use This Medicine


  • Your doctor will tell you how much to use and how often.
  • Do not start taking this medicine during an attack of gout. Wait until the attack has stopped.
  • May be taken with food to avoid stomach upset.
  • Drink 8 to 10 glasses of fluid (such as water, juice, or pop) every day while you take this medicine.
  • Your doctor also may recommend the use of antacids or potassium citrate.

If a dose is missed:

  • Take the missed dose as soon as possible.
  • If it is almost time for your next dose, wait until then to take your medicine and skip the missed dose.
  • You should not use two doses at the same time.

How to Store and Dispose of This Medicine

  • Store your medicine at room temperature, away from heat, moisture, and direct light.
  • Keep all medicine out of the reach of children.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • You should not use aspirin; instead take acetaminophen (Tylenol®) for pain.
  • Avoid drinking alcohol while taking this medicine.

Warnings While Using This Medicine

  • If you are breastfeeding, talk to your doctor before taking this medicine.
  • Avoid becoming pregnant while using this medicine. If you become pregnant, tell your doctor right away.
  • This medicine may cause incorrect results on certain blood or urine tests, such as those used by people with diabetes.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Itching and skin rash
  • Unexplained fever
  • Trouble breathing
  • Numbness or tingling in hands or feet
  • Fast heartbeat
  • Severe stomach pain or vomiting
  • Muscle weakness
  • Severe diarrhea

If you notice these less serious side effects, talk with your doctor:

  • Dizziness or headache
  • Flushed face
  • Nausea or diarrhea

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last Reviewed on 06/12/2013

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This page was last updated: June 18, 2013

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