Prasugrel (By mouth)


Prasugrel (PRA-soo-grel)

Prevents strokes and heart attacks in patients who need to have percutaneous coronary intervention (PCI).

Brand Name(s)


There may be other brand names for this medicine.

When This Medicine Should Not Be Used

Do not use this medicine if you have had an allergic reaction to prasugrel. Do not use this medicine if you have active bleeding (such as bleeding in your head, stomach, or bowel) or a history of stroke (including a "mini-stroke").

How to Use This Medicine


  • Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.
  • Your doctor may tell you to take aspirin with this medicine.
  • This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the Medication Guide if you do not have one.

If a dose is missed:

  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep the tablets in the original container.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you also use an NSAID pain or arthritis medicine (such as aspirin, diclofenac, ibuprofen, naproxen, Advil®, Aleve®, Celebrex®, Voltaren®), blood thinners (such as heparin, warfarin, Coumadin®, Jantoven®), or other medicines to prevent or treat blood clots (such as alteplase, reteplase, Activase®, Retavase®).

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding or if you have kidney disease, liver disease, or a history of heart attacks or bleeding problems. Tell your doctor if you are allergic to clopidogrel (Plavix®) or ticlopidine (Ticlid®).
  • This medicine may increase your risk of bleeding. The risk increases if you are 75 years of age or older, if you have had a recent trauma or surgery (such as CABG), stomach or bowel bleeding that keeps coming back, stomach ulcer, severe liver problems, or moderate to severe kidney problems, if you weigh less than 60 kilograms (kg) or 132 pounds (lbs), or if you take other medicines that increase your risk of bleeding (such as blood thinners or NSAIDs). Tell your doctor if you have any of these conditions before you use this medicine.
  • Check with your doctor right away if you have confusion, dark or bloody urine, trouble speaking, fever, pale skin, pinpoint red spots on the skin, seizures, weakness, or yellow eyes or skin. These maybe symptoms of a serious condition called thrombotic thrombocytopenic purpura (TTP).
  • Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests.
  • Do not stop taking this medicine without checking with your doctor first. Your risk for clots increases if you stop this medicine suddenly.
  • Your doctor will need to check your blood or urine at regular visits while you are using this medicine. Be sure to keep all appointments.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blood in your urine or stools
  • Chest pain
  • Fast, slow, pounding, or uneven heartbeat
  • Lightheadedness, dizziness, or fainting
  • Nosebleeds
  • Pinpoint red spots on the skin
  • Seizures
  • Trouble breathing, tiredness, fever, and yellow skin or eyes
  • Unusual bleeding or bruising
  • Vomiting of material that looks like coffee grounds

If you notice these less serious side effects, talk with your doctor:

  • Back pain
  • Headache

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last Reviewed on 06/12/2013

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