Pramlintide (Injection)


Pramlintide (PRAM-lin-tide)

Used to control blood sugar in people with type 1 and type 2 diabetes. This medicine is always used with insulin.

Brand Name(s)

Symlin, SymlinPen

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

You should not use this medicine if you have had an allergic reaction to pramlintide or to metacresol. You should not use this medicine if you have a condition called gastroparesis, which causes your stomach to empty more slowly than usual. This medicine is not for use by children or by anyone who cannot recognize the signs of low blood sugar.

How to Use This Medicine


  • Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to. This medicine is given as a shot under your skin, in your stomach or thigh.
  • This medicine comes in a vial or in a prefilled pen that you will use to inject it. Your doctor will tell which type of this medicine is right for you.
  • You may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.
  • Do not use this medicine if it looks cloudy or has changed color.
  • You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas.
  • Use a new needle and syringe each time you inject your medicine.
  • When you first start using this medicine, you will need to adjust your insulin dose. Do not change the timing or amount of any of your medicines without your doctor's advice. It is very important that you follow your doctor's instructions about all medicines you use to control your diabetes.
  • Follow carefully the special meal plan your doctor gave you. This is the most important part of controlling your condition, and is necessary if the medicine is to work properly. Also, exercise regularly and test for sugar in your blood or urine as directed.
  • You must check your glucose often to be sure you are not using too much of this or other medicines. Monitor your glucose before or after a meal or at bedtime, but check it at least once daily.
  • Never give pramlintide and insulin together in the same syringe. These medicines must be given as separate injections.
  • This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the Medication Guide if you do not have one.

If a dose is missed:

  • If you miss a dose or forget to use your medicine, wait until it is time for your next meal and skip the missed dose. Do not use extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • Store this medicine in the refrigerator. Protect it from light and keep it in the original carton. Do not freeze this medicine, and do not use the medicine if it has been frozen.
  • After using this medicine for the first time, you may store it in a closed container at room temperature. Keep it away from heat and protect it from light.
  • Throw this medicine away after using it for 30 days, even if there is some medicine left in it.
  • Do not use the medicine if it has been exposed to freezing or to very hot temperature.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine, containers, and other supplies. You will also need to throw away old medicine after the expiration date has passed.
  • Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets. Follow any special instructions about how to throw away empty medicine bottles, tubes, or bags.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are using atropine, disopyramide (Norpace®), pentoxifylline (Trental®), propoxyphene (Darvon®), Prozac®, a sulfa drug, or medicine that contains aspirin (salicylic acid). Make sure your doctor knows if you are also using an MAO inhibitor (such as Eldepryl®, Marplan®, Nardil®, Parnate®), or blood pressure medicine (such as enalapril, lisinopril, Accupril®, Capoten®, Lotrel®, Zestril®, Vasotec®).
  • If you use any type of medicine for pain, use it at least 1 hour before or 2 hours after your pramlintide injection.

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you plan to become pregnant while using this medicine. Tell your doctor if you have dexterity (skill in using the hands) or vision problems.
  • Watch for signs of low blood sugar for at least 3 hours after using this medicine.
  • You may be more likely to have low blood sugar during times of stress or if you miss a meal, drink alcohol, exercise more, or forget to use your insulin.
  • Avoid driving, using machines, or doing anything else that could be dangerous until you know how this medicine affects your blood sugar.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Dizziness, fainting, or seizures.
  • Fever, chills, cough, sore throat, and body aches.
  • Feeling irritable, weak, shaky, extremely hungry, or unable to concentrate.
  • Severe nausea, vomiting, or diarrhea.
  • Unusual tiredness or weakness.
  • Warmth or redness in your face, neck, or chest.

If you notice these less serious side effects, talk with your doctor:

  • Headache.
  • Loss of appetite, weight loss.
  • Mild nausea, vomiting, or stomach pain.
  • Redness, swelling, or itching of your skin where the shot was given.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last Reviewed on 06/12/2013

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