Paclitaxel Protein-bound (Injection)

Introduction

Paclitaxel Protein-Bound (pak-li-TAX-el PROE-teen - bownd)

Treats breast cancer and lung cancer.

Brand Name(s)

Abraxane

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

You should not receive this medicine if you have had an allergic reaction to paclitaxel protein-bound injection. You should not receive this medicine if you are pregnant, or if you have a low number of white blood cells.

How to Use This Medicine

Injectable

  • Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
  • You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.
  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given through a needle placed in one of your veins.
  • This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.

If a dose is missed:

  • This medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using cimetidine (Tagamet®), fluoxetine (Prozac®), gemfibrozil (Lopid®), rifampicin (Rifadin®, Rimactane®), verapamil (Calan®), medicine to treat an infection (such as erythromycin, itraconazole, ketoconazole, voriconazole, Nizoral®), medicine to treat HIV infection (such as efavirenz, indinavir, nelfinavir, nevirapine, ritonavir, saquinavir, Atripla®, Norvir®), or medicine to treat seizures (such as carbamazepine, phenytoin, Dilantin®, Tegretol®).

Warnings While Using This Medicine

  • This medicine can cause problems, such as birth defects, if it is used by the mother while she is pregnant or by the father when his sexual partner becomes pregnant. Tell your doctor right away if a pregnancy occurs during your treatment.
  • Make sure your doctor knows if you are breastfeeding, or if you have liver disease, kidney disease, or neuropathy or other nerve problems.
  • This medicine lowers the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily. To help with these problems, avoid being near people who are sick or have infections. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.
  • This medicine is made from donated human blood. Some human blood products have transmitted viruses to people who have received them. Human donors and donated blood are both tested for viruses before the medicine is prepared. Although the risk of getting a virus is low, talk with your doctor if you are concerned.
  • Check with your doctor right away if you have burning, numbness, tingling, or painful sensations in the arms, hands, legs, or feet. These could be symptoms of sensory neuropathy.
  • Cancer medicines can cause nausea and/or vomiting in most people, sometimes even after receiving medicines to prevent it. Ask your doctor or nurse about other ways to control these side effects.
  • Your doctor will need to check your blood at regular visits while you are using this medicine. Be sure to keep all appointments.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Fever, chills, cough, sore throat, or body aches
  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet
  • Ongoing vomiting or diarrhea, extreme thirst
  • Slow, fast, or uneven heartbeat
  • Trouble breathing, lightheadedness
  • Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

  • Diarrhea, vomiting
  • Hair loss
  • Joint or muscle pain
  • Pain, itching, burning, swelling, or a lump under your skin where the needle is placed
  • Weakness, tiredness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last Reviewed on 06/12/2013

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This page was last updated: September 18, 2013

         
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