Oxycodone, slow release (By mouth)
Oxycodone Hydrochloride (ox-i-KOE-done hye-droe-KLOR-ide)
Treats moderate to severe pain when around-the-clock pain relief is needed for a long period of time. Slow-release oxycodone is a narcotic medicine that should not be taken more often than every 12 hours.
There may be other brand names for this medicine.
When This Medicine Should Not Be Used
Do not use this medicine if you have had an allergic reaction to oxycodone, codeine, dihydrocodeine, hydrocodone, or morphine. Do not use this medicine if you are breastfeeding, or if you have serious breathing problems or paralytic ileus.
How to Use This Medicine
Long Acting Tablet
- Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.
- An overdose can be dangerous. Follow these directions carefully so you do not get too much medicine at one time.
- Swallow the extended-release tablet whole. Do not crush, break, or chew it.Do not take any tablet that is chipped or broken.
- Do not presoak, lick, or wet the tablet before you place it in your mouth.
- You may take this medicine with food or milk if it upsets your stomach.
- This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the Medication Guide if you do not have one.
If a dose is missed:
- If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
- This medicine can cause serious side effects if taken by anyone who is not used to narcotic pain medicines. Store the medicine in a safe and secure place to prevent others from getting it. Keep it away from pets.
- Do not throw any unused medicine in the trash. Flush it down the toilet, or take it to a community take-back program if available.
- Keep all medicine away from children and never share your medicine with anyone.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you are also using butorphanol (Stadol®), nalbuphine (Nubain®), pentazocine (Talwin®), a muscle relaxer (such as carisoprodol, cyclobenzaprine, metaxalone, methocarbamol, Skelaxin®, Soma®), or an MAO inhibitor (such as Eldepryl®, Marplan®, Nardil®, Parnate®).
- Tell your doctor if you use a phenothiazine medicine such as promethazine, Phenergan®, or Thorazine®. These medicines may be used to treat severe vomiting, coughing, psychiatric problems, or other conditions.
- Tell your doctor if you are also using medicine to treat an infection (such as clarithromycin, erythromycin, itraconazole, ketoconazole, voriconazole, Nizoral®), medicine to treat HIV/AIDS (such as atazanavir, indinavir, nelfinavir, ritonavir, saquinavir, Crixivan®, Kaletra®, Norvir®, Viracept®), medicine to treat seizures (such as carbamazepine, phenytoin, Dilantin®, Tegretol®), medicine to treat tuberculosis (such as rifampin, Rifadin®, Rimactane®), or a diuretic (water pill, such as furosemide, hydrochlorothiazide, torsemide, Lasix®).
- Tell your doctor if you are also using any other medicine to treat incontinence, or other medicine that can cause dry mouth or constipation such as atropine, dicyclomine, glycopyrrolate, scopolamine, Bentyl®, Robinul®, or Transderm Scop®.
- Do not drink alcohol while you are using this medicine.
- Tell your doctor if you are using any medicines that make you sleepy. These include sleeping pills, cold and allergy medicine, narcotic pain relievers, and sedatives.
Warnings While Using This Medicine
- Make sure your doctor knows if you are pregnant or if you have kidney disease, liver disease, breathing problems or lung disease (especially if you have COPD, cor pulmonale, asthma), low blood pressure, problems with urination, underactive thyroid, Addison disease, prostate problems, or have digestion problems, including esophagus cancer, colon cancer, or pancreas problems. Tell your doctor if you have a history of head injury, brain lesion, seizures, or alcohol or drug abuse.
- Do not use more of this medicine or take it more often than your doctor tells you to. This can be life-threatening. Symptoms of an overdose include extreme dizziness or weakness, slow heartbeat or breathing, trouble breathing, seizures, and cold, clammy skin. Call your doctor right away if you notice these symptoms.
- This medicine may be habit-forming. If you feel that the medicine is not working as well, do not use more than your prescribed dose. Call your doctor for instructions.
- Do not stop using this medicine suddenly without asking your doctor. You may need to slowly decrease your dose before stopping it completely.
- This medicine may make you feel dizzy, drowsy, or faint. Avoid driving, using machines, or doing anything else that could be dangerous until you know how this medicine affects you. Stand or sit up slowly. Lie down if needed until you feel better.
- This medicine may cause constipation. This is more common if you use it for a long time. Ask your doctor if you should also use a laxative to prevent and treat constipation.
Possible Side Effects While Using This Medicine
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blue lips, fingernails, or skin
- Extreme weakness, shallow breathing, uneven heartbeat, sweating, cold or clammy skin
- Severe confusion, lightheadedness, dizziness, fainting
- Severe constipation or vomiting
- Trouble breathing
If you notice these less serious side effects, talk with your doctor:
- Dry mouth
- Itching skin
- Mild constipation, nausea, vomiting
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
- Last Reviewed on 06/12/2013
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This page was last updated: June 18, 2013