Olmesartan/amlodipine/hydrochlorothiazide (By mouth)
Amlodipine (am-LOE-di-peen), Hydrochlorothiazide (hye-droe-klor-oh-THYE-a-zide), Olmesartan (ol-me-SAR-tan)
Treats high blood pressure. A lower blood pressure can reduce the risk of stroke and heart attack. This medicine is a combination of an angiotensin receptor blocker (ARB), a calcium channel blocker (CCB), and a thiazide diuretic (water pill).
There may be other brand names for this medicine.
When This Medicine Should Not Be Used
Do not use this medicine if you have had an allergic reaction to olmesartan, amlodipine, hydrochlorothiazide, or a sulfonamide (sulfa) drug. Do not use this medicine if you are pregnant, have severe kidney disease, or not able to urinate. Do not use this medicine together with aliskiren (Tekturna®) if you have diabetes.
How to Use This Medicine
- Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.
- Take this medicine at the same time each day.
- Carefully follow your doctor's instructions about any special diet.Drink plenty of fluids if you exercise, sweat more than usual, or have diarrhea or vomiting.
- This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.
If a dose is missed:
- If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
- Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
- Keep all medicine away from children and never share your medicine with anyone.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you also use simvastatin (Vytorin®, Zocor®) or other medicine to lower cholesterol (such as cholestyramine, colesevelam, colestipol, Colestid®, Questran®). Also tell your doctor if you take another medicine for high blood pressure, including a diuretic (water pill, such as amiloride, spironolactone, triamterene, Aldactone®).
- Make sure your doctor knows if you also use lithium (Eskalith®, Lithobid®), an NSAID pain or arthritis medicine (such as aspirin, diclofenac, ibuprofen, naproxen, Advil®, Aleve®, Celebrex®, Voltaren®), insulin or an oral diabetes medicine (such as glimepiride, glyburide, metformin, Actos®, Janumet®, Januvia®), or a steroid medicine (such as hydrocortisone, methylprednisolone, prednisolone, prednisone).
- If you also take colesevelam (Welchol®), take it at least 4 hours after you take Tribenzor®.
- Ask your doctor before you use any medicine, supplement, or salt substitute that contains potassium.
- Alcohol, narcotic pain medicine, or sleeping pills may cause you to feel more lightheaded, dizzy, or faint when used with this medicine.
Warnings While Using This Medicine
- Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.
- Make sure your doctor knows if you are breastfeeding or if you have had a heart attack. Tell your doctor if you have kidney problems, liver disease (including cirrhosis), diabetes, glaucoma, gout, lupus, congestive heart failure, heart or blood vessel disease, a mineral imbalance (such as high calcium or low potassium, magnesium, or sodium in the blood), or a history of allergies or asthma.
- This medicine could lower your blood pressure too much and cause you to feel dizzy or lightheaded. Stand or sit up slowly if you are dizzy. This is more likely to happen when you begin to use the medicine or if you become dehydrated.
- This medicine may make you drowsy. Do not drive, use machines, or do anything else that could be dangerous until you know how this medicine affects you.
- Check with your doctor right away if you have chest pain that is worse than usual, trouble breathing, nausea, faintness, unusual sweating, or pain in your arm, jaw, back, or neck. This medicine may worsen the symptoms of an existing heart problem.
- Check with your doctor immediately if you have vision changes, such as blurred vision, difficulty reading, or eye pain, during or after treatment. This could be a sign of a serious eye problem.
- Do not stop using the medicine without asking your doctor, even if you feel well. This medicine will not cure your high blood pressure, but it will help keep it in the normal range. You may have to take blood pressure medicine for the rest of your life.
- Your doctor will need to check your blood or urine at regular visits while you are using this medicine. Be sure to keep all appointments.
Possible Side Effects While Using This Medicine
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Blurred vision or changes in vision
- Change in how much or how often you urinate, pain when urinating, bloody or cloudy urine
- Chest pain that may spread to your arms, jaw, back, or neck, trouble breathing, nausea, unusual sweating
- Confusion, weakness, and muscle twitching
- Dry mouth, increased thirst, muscle cramps, nausea, vomiting
- Fast, slow, or uneven heartbeat
- Lightheadedness, dizziness, or fainting
- Rapid weight gain, swelling in your hands, ankles, or feet
If you notice these less serious side effects, talk with your doctor:
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
- Last Reviewed on 06/12/2013
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- 2013 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
This page was last updated: June 18, 2013