Olanzapine (Injection)

Introduction

Olanzapine (oh-LAN-za-peen)

Treats agitation (being overexcited, tense, hostile, or anxious) in patients with schizophrenia or bipolar disorder.

Brand Name(s)

Zyprexa IntraMuscular, Zyprexa Relprevv

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

You should not use this medicine if you have had an allergic reaction to olanzapine.

How to Use This Medicine

Injectable

  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot into one of your muscles.
  • A nurse or other trained health professional will give you this medicine.
  • Your doctor will give you a few doses of this medicine until your condition improves, and then switch you to an oral medicine that works the same way.
  • Zyprexa Relprevv® is available only under a special restricted distribution program called Zyprexa Relprevv® patient care program.
  • Use only the brand of this medicine that your doctor prescribed. Different brands may not work the same way.
  • This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the Medication Guide if you do not have one.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • You must be careful if you are also using other medicine that might cause similar side effects as olanzapine. This includes medicine that might cause low blood pressure, overheating, or liver problems. Make sure your doctor knows about all other medicines you are using.
  • Make sure your doctor knows if you are using carbamazepine (Tegretol®), fluoxetine (Prozac®), fluvoxamine (Luvox®), levodopa (Sinemet®, Stalevo®), omeprazole (Prilosec®), or rifampin (Rifadin®).
  • Make sure your doctor knows if you are also using medicine to treat high blood pressure such as atenolol, hydrochlorothiazide [HCTZ], lisinopril, metoprolol, quinapril, Accupril®, Cozaar®, Diovan®, Lotrel®, Norvasc®, Toprol®, or Zestril®.
  • Make sure your doctor knows if you are using medicine to treat anxiety (such as alprazolam, diazepam, Valium®, or Xanax®). Tell your doctor if you are using any medicines that make you sleepy. These include sleeping pills, cold and allergy medicine, narcotic pain relievers, and sedatives.
  • Do not drink alcohol while you are using this medicine.
  • Tell your doctor if you smoke tobacco. You might need a different amount of this medicine if you smoke.

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant, or if you have diabetes, liver disease, prostate problems, narrow-angle glaucoma, or a history of neuroleptic malignant syndrome (NMS), breast cancer, seizures, or severe constipation. Tell your doctor if you have any kind of heart or circulation problems, including low blood pressure, heart failure, heart rhythm problems, or a history of a heart attack or stroke.
  • Some side effects are more likely to happen in elderly people with dementia or other memory problems. Make sure the doctor knows if the person who will be using this medicine has forgetfulness or confusion related to aging (such as Alzheimer's disease or dementia).
  • Do not breastfeed while you are using this medicine.
  • For some patients, this medicine can increase thoughts of suicide. Tell your doctor right away if you start to feel more depressed and have thoughts about hurting yourself. Report any unusual thoughts or behaviors that trouble you, especially if they are new or are getting worse quickly. Make sure the doctor knows if you have trouble sleeping, get upset easily, have a big increase in energy, or start to act reckless. Also tell the doctor if you have sudden or strong feelings, such as feeling nervous, angry, restless, violent, or scared. Let the doctor know if you or anyone in your family has bipolar disorder (manic-depressive illness) or has tried to commit suicide.
  • This medicine may increase your cholesterol and fats in the blood. If this condition occurs, your doctor may give you some medicines that can lower the amount of cholesterol and fats in the blood.
  • This medicine may increase your weight. Your doctor may need to check your weight regularly during treatment with this medicine.
  • This medicine may increase the amount of sugar in your blood. Check with your doctor right away if you have increased thirst or increased urination. If you have diabetes, you may notice a change in the results of your urine or blood sugar tests. If you have any questions, check with your doctor.
  • This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert. You may also feel lightheaded when getting up suddenly from a lying or sitting position, so stand up slowly.
  • Tardive dyskinesia (a movement disorder) may occur and may not go away after you stop using the medicine. Check with your doctor right away if you have any of the following symptoms while taking this medicine: lip smacking or puckering, puffing of the cheeks, rapid or worm-like movements of the tongue, uncontrolled chewing movements, or uncontrolled movements of the arms and legs.
  • Check with your doctor right away if you have any of the following symptoms while using this medicine: convulsions (seizures), difficulty with breathing, a fast heartbeat, a high fever, high or low blood pressure, increased sweating, loss of bladder control, severe muscle stiffness, unusually pale skin, or tiredness. These could be symptoms of a serious condition called neuroleptic malignant syndrome (NMS).
  • This medicine may cause post-injection delirium/sedation syndrome. Tell your doctor right away if you have the following symptoms: convulsions (seizures), dizziness, drowsiness, sleepiness, or confusion as to time, place, or person after receiving the injection.
  • This medicine lowers the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily. To help with these problems, avoid being near people who are sick or have infections. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.
  • You might get overheated while using this medicine. Drink plenty of water during hot weather, while exercising, or while using a hot tub or sauna. If your body gets too hot, you might feel dizzy, weak, tired, or confused. You might have an upset stomach or vomit. Call your doctor if drinking cool water and moving away from the heat does not cool you down.
  • Your doctor will need to check your progress at regular visits while you are using this medicine. Be sure to keep all appointments. Blood tests may be needed to check for unwanted effects.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blurred or other changes in vision.
  • Change in how much or how often you urinate.
  • Fast or uneven heartbeat.
  • Fever, sweating, confusion, or muscle stiffness.
  • Increased restlessness or excessive movements.
  • Jerky muscle movement you cannot control (often in your face, tongue, or jaw).
  • Lightheadedness or fainting.
  • Numbness or weakness in your arm or leg, or on one side of your body.
  • Severe sleepiness, slurred speech, or trouble with breathing.
  • Shakiness, problems with balance or walking.
  • Swelling in your hands, ankles, or feet.
  • Swollen breasts, or liquid discharge from your nipples (men or women).
  • Trouble with swallowing.

If you notice these less serious side effects, talk with your doctor:

  • Back pain.
  • Constipation, upset stomach.
  • Dry mouth, increased thirst, or watering of the mouth.
  • Increased appetite.
  • Missed menstrual period.
  • Pain where the shot is given.
  • Redness or swelling in your eye.
  • Sleepiness or unusual drowsiness.
  • Stuffy or runny nose.
  • Trouble with sleeping.
  • Weakness.
  • Weight gain.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last Reviewed on 06/12/2013

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This page was last updated: June 18, 2013

         
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