Nitroglycerin (By mouth)
Treats or prevents angina (chest pain). This medicine is a nitrate.
There may be other brand names for this medicine.
When This Medicine Should Not Be Used
You should not use this medicine if you have had an allergic reaction to nitroglycerin or similar medicines (such as Isordil®, Sorbitrate®, or Monoket®). You should not use this medicine if you are also using Viagra®, Cialis®, or Levitra®.
How to Use This Medicine
Tablet, Long Acting Capsule, Long Acting Tablet
- Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
- Most people use this medicine for only part of the day or as needed.
- It is best to take the extended-release capsule or extended-release tablet on an empty stomach with a full glass of water.
- Swallow the extended-release capsule or extended-release tablet whole. Do not crush, chew, or break.
- Place the buccal tablet between your gum and upper cheek or upper lip. Let the tablet dissolve slowly in your mouth over several hours. Do not chew, crush, or swallow the tablet or put it under your tongue. Avoid drinking anything hot while the tablet is in your mouth and do not touch the tablet with your tongue.
- Do not go to sleep with a buccal tablet in your mouth.
If a dose is missed:
- If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose.
- Do not use extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine
- Store the medicine at room temperature in a closed container, away from heat, moisture, and direct light. Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
- Keep all medicine out of the reach of children and never share your medicine with anyone.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you are also using aspirin, alteplase (Activase®), heparin, diuretics or "water pills" (such as furosemide, hydrochlorothiazide, Hyzaar®), heart or blood pressure medicine (such as atenolol, metoprolol, verapamil, Adalat®, Cardizem®, Lotrel®, Plendil®, Procardia®, Tiazac®, Toprol®), phenothiazines (such as Compazine®, Phenergan®, Serentil®, Thorazine®), ergot medicines (such as Cafergot® or Wigraine®), or other nitrates (such as isosorbide).
- If you are using the buccal tablet, tell your doctor if you are also using any medicine that makes your mouth dry, such as some medicines that treat depression (such as amitriptyline, imipramine, Norpramin®, Vivactil®).
- Do not drink alcohol while you are using this medicine.
Warnings While Using This Medicine
- Make sure your doctor knows if you are pregnant or breastfeeding, or if you have low blood pressure, congestive heart failure (CHF), enlarged heart, digestion problems, or kidney disease.
- Medicines that treat chest pain sometimes cause headaches. These headaches are a sign that the medicine is working. Do not stop using the medicine or change the time you use it in order to avoid the headaches. If the pain is severe, talk to your doctor.
- Do not stop using this medicine suddenly without asking your doctor. You may need to slowly decrease your dose before stopping it completely.
- This medicine may make you dizzy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert. You may feel lightheaded when standing, so stand up slowly.
Possible Side Effects While Using This Medicine
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in face or hands, swelling or tingling in the mouth or throat, tightness in chest, trouble breathing
- Blue lips or fingernails, trouble breathing
- Blurred vision, dry mouth
- Severe or ongoing dizziness, lightheadedness, or fainting
- Slow heartbeat, increased chest pain
- Throbbing, severe, or ongoing headache, confusion, low fever, or trouble seeing
If you notice these less serious side effects, talk with your doctor:
- Facial flushing, nausea, vomiting, weakness
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
- Last Reviewed on 06/12/2013
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This page was last updated: June 18, 2013