Morphine/naltrexone (By mouth)
Morphine Sulfate (MOR-feen SUL-fate), Naltrexone Hydrochloride (nal-TREX-one hye-droe-KLOR-ide)
Treats moderate to severe pain when around-the-clock pain relief is needed for a long period of time.
There may be other brand names for this medicine.
When This Medicine Should Not Be Used
Do not use this medicine if you have had an allergic reaction to morphine, morphine salts, or naltrexone. Do not use this medicine if you have serious breathing or lung problems (such as severe asthma, respiratory depression) or paralytic ileus.
How to Use This Medicine
Long Acting Capsule
- Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.
- Swallow the extended-release capsule whole. Do not crush, break, or chew it.
- If you cannot swallow the extended-release capsule, you may open it and pour the medicine into a small amount of applesauce. Stir this mixture well and swallow it without chewing. Drink a glass of water to make sure you have swallowed the pellets completely.
- This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the Medication Guide if you do not have one.
If a dose is missed:
- If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
- Flush all leftover medicine down the toilet after you have finished your treatment. Also flush old medicine after the expiration date has passed. This medicine is one of only a few medicines that should be disposed of this way.
- Keep all medicine away from children and never share your medicine with anyone.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you also use butorphanol (Stadol®), cimetidine (Tagamet®), nalbuphine (Nubain®), pentazocine (Talwin®), quinidine (Cardioquin®), muscle relaxants (such as carisoprodol, cyclobenzaprine, metaxalone, methocarbamol, Skelaxin®, Soma®), a diuretic (water pill, such as furosemide, torsemide, Demadex®, Lasix®), or a phenothiazine medicine (such as prochlorperazine, promethazine, Compazine®, Mellaril®, Phenergan®, Thorazine®, Trilafon®).
- Tell your doctor if you use atropine, dicyclomine (Bentyl®), glycopyrrolate (Robinul®), hyoscyamine (Cystospaz®), propantheline (Pro-Banthine®), or scopolamine (Transderm Scop®).
- You should not use this medicine if you have used an MAO inhibitor (MAOI) such as Eldepryl®, Marplan®, Nardil®, or Parnate® within the past 14 days.
- Do not drink alcohol while you are using this medicine.
- Tell your doctor if you are using any medicines that make you sleepy. These include sleeping pills, cold and allergy medicine, narcotic pain relievers, and sedatives.
Warnings While Using This Medicine
- Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart disease, low blood pressure, an underactive thyroid, pancreas problems, an enlarged prostate, problems with urination, or stomach or bowel problems. Tell your doctor if you have mental illness or a history of head injury, brain tumor, or seizures. Tell your doctor if you have a history of drug or alcohol abuse.
- Tell your doctor if you have a breathing problem, such as COPD, cor pulmonale, hypoxia or hypercapnia (low oxygen or high carbon dioxide level in your blood), or hypoventilation (breathing too slowly).
- It is against the law and dangerous for anyone else to use your medicine. Keep your unused medicine in a safe and secure place. People who are addicted to drugs might want to steal this medicine.
- This medicine may be habit-forming. If you feel that the medicine is not working as well, do not use more than your prescribed dose. Call your doctor for instructions.
- Do not use more of this medicine or take it more often than your doctor tells you to. This can be life-threatening. Symptoms of an overdose include extreme dizziness or weakness, trouble breathing, slow heartbeat, seizures, and cold, clammy skin. Call your doctor right away if you notice these symptoms.
- This medicine may make you dizzy, drowsy, or lightheaded. Do not drive, use machines, or do anything else that could be dangerous until you know how this medicine affects you. Stand or sit up slowly if you feel lightheaded or dizzy.
- This medicine may cause constipation. This is more common if you use it for a long time. Ask your doctor if you should also use a laxative to prevent and treat constipation.
- Do not stop using this medicine suddenly without asking your doctor. You may need to slowly decrease your dose before stopping it completely.
- Your doctor will need to check your progress at regular visits while you are using this medicine. Be sure to keep all appointments.
Possible Side Effects While Using This Medicine
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Anxiety, depression, mood or behavior changes
- Change in how much or how often you urinate
- Lightheadedness, dizziness, fainting
- Trouble breathing
- Unusual tiredness or weakness
If you notice these less serious side effects, talk with your doctor:
- Nausea, vomiting
- Sleepiness or unusual drowsiness
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
- Last Reviewed on 06/12/2013
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This page was last updated: June 18, 2013