Morphine, slow release (By mouth)

Introduction

Morphine (MOR-feen)

Treats moderate to severe pain. This medicine is a narcotic analgesic.

Brand Name(s)

Avinza, Kadian, MS Contin

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

Do not use this medicine if you have had an allergic reaction to morphine, codeine, hydrocodone, dihydrocodeine, oxycodone, Tylenol® No. 3, Tylox®, or Vicodin®. Do not use this medicine if you have severe lung or breathing problems (such as severe asthma) or paralytic ileus.

How to Use This Medicine

Long Acting Capsule, 24 Hour Capsule, Long Acting Tablet

  • Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.
  • Take this medicine at the same time each day.
  • Swallow the extended-release tablet whole. Do not crush, break, or chew it.Do not take any tablet that has been chipped or broken. If you take a broken tablet, the medicine can be released into your blood too quickly, which could be dangerous.
  • While taking the extended-release form of this medicine, part of the tablet may pass into your stools. This is normal and is nothing to worry about.
  • Swallow the extended-release capsule whole. Do not crush, break, or chew it.
  • If you cannot swallow the extended-release capsule, you may open it and pour the medicine into a small amount of soft food such as pudding, yogurt, or applesauce. Stir this mixture well and swallow it without chewing.You should not receive this medicine through a feeding tube.
  • You may take this medicine with food or milk if it upsets your stomach. Drink plenty of water and get plenty of exercise to avoid constipation.
  • Morphine extended-release capsules work differently from the regular morphine tablets, even at the same dose. Do not switch from one form to the other unless your doctor tells you to.
  • This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the Medication Guide if you do not have one.

If a dose is missed:

  • If you miss a dose of this medicine, skip the missed dose and take your next dose at your usual time the next day. Do not double doses.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • This medicine can cause serious side effects if taken by adults or children who are not used to strong narcotic pain medicines. Make sure you store the medicine in a safe and secure place to prevent others from getting it. Keep the medicine away from pets.
  • Do not throw any unused or expired medicine in the trash. Take it to a community take-back program or flush it down the toilet.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you also use buprenorphine (Buprenex®), butorphanol (Stadol®), cimetidine (Tagamet®), cyclosporine (Gengraf®, Neoral®, Sandimmune®), esmolol (Brevibloc®), methohexital (Brevital®), nalbuphine (Nubain®), pentazocine (Talwin®), quinidine (Cardioquin®), rifampin (Rifamate®, Rifater®), tramadol (Ultram®), muscle relaxants (such as carisoprodol, cyclobenzaprine, metaxalone, methocarbamol, Skelaxin®, Soma®), a diuretic or water pill (such as furosemide, torsemide, Demadex®, Lasix®), or a phenothiazine medicine (such as promethazine, Phenergan®, Thorazine®). Tell your doctor if you use atropine, dicyclomine (Bentyl®), glycopyrrolate (Robinul®), hyoscyamine (Cystospaz®), propantheline (Pro-Banthine®), or scopolamine (Transderm Scop®).
  • Do not use this medicine if you are using or have used an MAO inhibitor (MAOI) such as Eldepryl®, Marplan®, Nardil®, or Parnate® within the past 14 days.
  • Do not drink alcohol while you are using this medicine.
  • Tell your doctor if you are using any medicines that make you sleepy. These include sleeping pills, cold and allergy medicine, narcotic pain relievers, and sedatives.

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding or if you have kidney disease, liver disease, heart disease, low blood pressure, lung disease (such as chronic obstructive pulmonary disease [COPD]), problems with urination, an underactive thyroid, Addison disease, gallbladder problems, pancreas problems, prostate problems, or a stomach or bowel problems. Tell your doctor if you have a history of head injury, brain tumor, depression or other mental illness, seizures, or alcohol or drug abuse.
  • This medicine may be habit-forming. If you feel that the medicine is not working as well, do not use more than your prescribed dose. Call your doctor for instructions.
  • This medicine may make you dizzy, drowsy, or lightheaded. Do not drive, use machines, or do anything else that could be dangerous until you know how this medicine affects you. Stand or sit up slowly if you feel lightheaded or dizzy.
  • This medicine may cause constipation. This is more common if you use it for a long time. Ask your doctor if you should also use a laxative to prevent and treat constipation.
  • Do not stop using this medicine suddenly without asking your doctor. You may need to slowly decrease your dose before stopping it completely.
  • Do not use more of this medicine or take it more often than your doctor tells you to. This can be life-threatening. Symptoms of an overdose include extreme dizziness or weakness, trouble breathing, slow heartbeat, seizures, and cold, clammy skin. Call your doctor right away if you notice these symptoms.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blue lips, fingernails, or skin
  • Change in how much or how often you urinate, bloody or cloudy urine
  • Confusion, trouble breathing, slow or shallow breathing, weakness, sweating, cold or clammy skin
  • Fast, slow, or uneven heartbeat
  • Fever, chills, cough, sore throat, and body aches
  • Lightheadedness, dizziness, fainting
  • Seizures
  • Swelling in your hands, ankles, or feet

If you notice these less serious side effects, talk with your doctor:

  • Back pain
  • Constipation, diarrhea, nausea, vomiting, loss of appetite, stomach pain
  • Headache, trouble sleeping
  • Sleepiness or unusual drowsiness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last Reviewed on 06/12/2013

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This page was last updated: September 18, 2013

         
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