Maprotiline (By mouth)

Introduction

Maprotiline (ma-PROE-ti-leen)

Treats depression and anxiety. This medicine is a tetracyclic antidepressant.

Brand Name(s)

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

You should not use this medicine if you have ever had an allergic reaction to maprotiline. Check with your doctor before taking this medicine if you have seizures (epilepsy), if you have recently had a heart attack, or if you are taking monoamine oxidase (MAO) inhibitors such as Marplan®, Parnate, Nardil®.

How to Use This Medicine

Tablet

  • Your doctor will tell you how much to take and how often. Take this medicine exactly as ordered by your doctor.
  • Do not stop taking maprotiline suddenly without first asking your doctor.
  • This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the Medication Guide if you do not have one.

If a dose is missed:

  • Take the missed dose as soon as possible.
  • If it is almost time for your next regular dose, wait until then to take the medicine and skip the missed dose.
  • You should not use two doses at the same time.

How to Store and Dispose of This Medicine

  • Store at room temperature in a closed container, away from heat, moisture, and direct light.
  • Keep all medicine out of the reach of children.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not drink alcohol while taking this medicine.
  • Make sure your doctor knows if you are taking other medicines that could make you drowsy, such as sleeping pills, tranquilizers, cold and allergy medicines, and pain killers.

Warnings While Using This Medicine

  • If you are pregnant or breastfeeding, talk to your doctor before taking this medicine.
  • Make sure your doctor knows if you have had heart problems, overactive thyroid, glaucoma, or if you have trouble urinating.
  • For some children, teenagers, and young adults, this medicine may increase thoughts of suicide. Tell the doctor right away if you start to feel more depressed or have thoughts about hurting yourself. Report any unusual thoughts or behaviors that trouble you, especially if they are new or get worse quickly. Tell the doctor if you have trouble sleeping, get upset easily, feel very energetic, or start to act reckless. Also report if you suddenly feel nervous, angry, restless, violent, or scared. Make sure the doctor knows if you have a family history of bipolar (manic-depressive) disorder or suicide.
  • Maprotiline may make you drowsy or dizzy. Be careful driving a car or operating machinery.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Skin rash, hives, or itching
  • Seizures
  • Irregular or rapid heartbeat
  • Psychosis (delusions, paranoia)

If you notice these less serious side effects, talk with your doctor:

  • Drowsiness, dizziness, or tiredness
  • Nausea, upset stomach, dry mouth
  • Constipation
  • Trouble urinating
  • Changes in vision such as trouble focusing
  • Weight gain

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last Reviewed on 06/12/2013

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This page was last updated: June 18, 2013

         
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