Lubiprostone (By mouth)


Lubiprostone (loo-bi-PROST-one)

Treats constipation. Also treats irritable bowel syndrome (IBS) with constipation in women. This medicine is a stool softener.

Brand Name(s)


When This Medicine Should Not Be Used

How to Use This Medicine

Capsule, Liquid Filled Capsule

  • Your doctor will tell you how much medicine to use. Do not use more than directed.
  • Take this medicine with food and water. This will help lessen the chance of nausea.
  • Swallow the capsule whole. Do not crush, break, or chew it.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you also use methadone (Dolophine®).

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have liver disease, stomach pain, nausea, vomiting, severe diarrhea, or a sudden change in bowel movements.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Severe diarrhea, stomach pain or swelling
  • Severe nausea or vomiting
  • Trouble breathing

If you notice these less serious side effects, talk with your doctor:

  • Headache
  • Mild nausea
  • Passing gas

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last reviewed on 12/4/2015

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