Loxapine (By breathing)

Introduction

Loxapine (LOX-a-peen)

Treats acute agitation in adult patients with schizophrenia or bipolar disorder.

Brand Name(s)

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

Do not use this medicine if you have had an allergic reaction to loxapine or amoxapine. Do not use this medicine if you have breathing problems, including chronic obstructive pulmonary disease (COPD) or asthma, or if you are taking medicine to treat breathing problems.

How to Use This Medicine

Powder

  • A doctor or other trained health professional will give you this medicine in a hospital. You will breathe it in through the mouth and into the lungs.
  • Your doctor will check you for breathing problems before you receive the medicine and for at least an hour afterwards.
  • This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the Medication Guide if you do not have one.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using a blood pressure medicine (such as amlodipine, atenolol, clonidine, hydrochlorothiazide, lisinopril, metoprolol, Benicar®, Cozaar®, Diovan®).
  • Tell your doctor if you are also using any medicine that causes dry mouth or constipation, including medicine to treat depression (such as amitriptyline, nortriptyline, Elavil®) or medicine to treat Parkinson disease (such as bromocriptine, levodopa, Parlodel®.
  • Do not drink alcohol while you are using this medicine.
  • Tell your doctor if you are using any medicines that make you sleepy. These include sleeping pills, cold and allergy medicine, narcotic pain relievers, and sedatives.

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have glaucoma, trouble urinating, or a history of seizures. Tell your doctor if you have heart disease or blood circulation problems, such as heart failure, heart rhythm problems, high or low blood pressure, or a history of heart attack or stroke.
  • This medicine may cause serious breathing problems. Tell your doctor right away if you have a cough, trouble breathing, tightness in your chest, or wheezing.
  • Check with your doctor right away if you have a high fever, sweating, confusion, uneven heartbeat, or muscle stiffness. These could be symptoms of a serious condition called neuroleptic malignant syndrome (NMS).
  • This medicine should not be used to treat dementia in elderly adults because of an increased risk for stroke and other side effects.
  • You might feel dizzy, lightheaded, or faint after you receive this medicine, especially when you get up suddenly. Stand or sit up slowly. If the problem continues or gets worse, check with your doctor. Avoid driving, using machines, or doing anything else that could be dangerous until you know how this medicine affects you.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Decrease in how much or how often you urinate
  • Fever, sweating, confusion, uneven heartbeat, muscle stiffness
  • Lightheadedness, dizziness, or fainting
  • Seizures
  • Trouble breathing, chest pain, coughing
  • Twitching or muscle movements you cannot control, problems with balance or walking

If you notice these less serious side effects, talk with your doctor:

  • Bad, bitter, or metallic taste
  • Dry mouth
  • Sleepiness or tiredness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last Reviewed on 06/12/2013

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This page was last updated: June 18, 2013

         
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