Lisinopril/hydrochlorothiazide (By mouth)


Hydrochlorothiazide (hye-droe-klor-oh-THYE-a-zide), Lisinopril (lye-SIN-oh-pril)

Treats high blood pressure. This medicine contains an ACE inhibitor and a diuretic (water pill).

Brand Name(s)

Prinzide, Zestoretic

When This Medicine Should Not Be Used

How to Use This Medicine


  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Do not use this medicine together with aliskiren if you have diabetes.
  • Some foods and medicines can affect how lisinopril/hydrochlorothiazide works. Tell your doctor if you are using any of the following:
    • Aliskiren, cholestyramine, colestipol, lithium
    • Another blood pressure medicine, including an angiotensin receptor blocker (ARB)
    • Insulin or oral diabetes medicines
    • NSAID pain or arthritis medicine (such as aspirin, celecoxib, diclofenac, ibuprofen, or naproxen)
    • Steroid medicine (such as hydrocortisone, methylprednisolone, prednisolone, prednisone)
  • Ask your doctor before you use any medicine, supplement, or salt substitute that contains potassium.
  • Alcohol, narcotic pain relievers, or sleeping pills may cause you to feel more lightheaded, dizzy, or faint when used with this medicine.

Warnings While Using This Medicine

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
  • Tell your doctor if you are breastfeeding, or if you have kidney problems, liver disease, diabetes, heart failure, heart or blood vessel disease, high cholesterol, gout, lupus, trouble urinating, or a history of allergies or asthma.
  • This medicine may cause the following problems:
    • Angioedema (severe swelling)
    • Serious liver problems
    • Glaucoma
  • This medicine could lower your blood pressure too much, especially when you first use it or if you are dehydrated. Stand or sit up slowly if you feel lightheaded or dizzy.
  • Do not stop using the medicine without asking your doctor, even if you feel well. This medicine will not cure your high blood pressure, but it will help keep it in the normal range. You may have to take blood pressure medicine for the rest of your life.
  • Tell any doctor or dentist who treats you that you are using this medicine.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Change in how much or how often you urinate, problems urinating
  • Confusion, weakness, uneven heartbeat, trouble breathing, numbness in your hands, feet, or lips
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Eye pain, vision changes, seeing halos around lights
  • Fever, chills, sore throat, or body aches
  • Lightheadedness, dizziness, or fainting
  • Severe stomach pain (with or without nausea or vomiting)

If you notice these less serious side effects, talk with your doctor:

  • Dry cough
  • Headache

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last reviewed on 7/4/2015

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