Levoleucovorin (Injection)

Introduction

Levoleucovorin (lee-voe-loo-koe-VOE-rin)

Given to prevent the harmful effects of methotrexate (a cancer medicine) in patients with bone cancer (osteosarcoma). Also given to patients who receive too much methotrexate for other conditions. Also used in combination with 5-fluorouracil (Adrucil®) to relieve and prevent symptoms of advanced metastatic (cancer that has already spread) cancer of the colon and rectum. This medicine acts in the body like folic acid (vitamin B9).

Brand Name(s)

Fusilev

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

You should not receive this medicine if you have had an allergic reaction to levoleucovorin or similar medicines such as folic acid (Folvite®) and folinic acid. You should not receive this medicine if you have certain blood problems such as anemia caused by a lack of vitamin B12.

How to Use This Medicine

Injectable

  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given through a needle placed in one of your veins.
  • A nurse or other trained health professional will give you this medicine.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are using 5-fluorouracil (Adrucil®) or a combination of trimethoprim and sulfamethoxazole (Bactrim® or Septra®). Tell your doctor if you are also using medicine to treat seizures (such as phenobarbital, phenytoin, primidone, Luminal®, Dilantin®, or Mysoline®).

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, dehydration, fluid around the lungs (pleural effusion), or fluid in the stomach (ascites).
  • Your doctor will need to check your blood or urine at regular visits while you are using this medicine. Be sure to keep all appointments.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Change in how much or how often you urinate.
  • Fever or chills.
  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet.
  • Seizures or fainting.
  • Shakiness or shivering.
  • Shortness of breath or troubled breathing.
  • Stomach pain, bloody or watery diarrhea.
  • Unusual tiredness or weakness.

If you notice these less serious side effects, talk with your doctor:

  • Change in taste.
  • Confusion.
  • Dry, cracked, or scaly skin.
  • Hair loss.
  • Loss of appetite.
  • Mild diarrhea, nausea, vomiting, or upset stomach.
  • Skin rash or itching.
  • Sores or white patches on your lips, mouth, or throat.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last Reviewed on 06/12/2013

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This page was last updated: September 18, 2013

         
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