Leuprolide/norethindrone (Injection, by mouth)

Introduction

Treats pain caused by endometriosis.

Brand Name(s)

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

You should not receive this medicine if you have had an allergic reaction to leuprolide or norethindrone. You should not receive this medicine if you are pregnant, may become pregnant, are breastfeeding, or have any unusual uterine bleeding that has not been checked by your doctor. You should not receive this medicine if you have liver disease or tumors, blood clotting problems, heart attack, stroke, or a history of breast cancer or other hormone-sensitive cancer.

How to Use This Medicine

  • Lupaneta Pack® is a kit that contains 2 medicines that work together.
  • Injection:
    • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot into one of your muscles.
    • A nurse or other trained health professional will give you this medicine.
    • This is a long-acting medicine that is given once a month or once every 3 months, for up to 6 months of treatment.
  • Tablet:
    • Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.This medicine should be taken every day while you are being treated with the injection medicine, for up to 6 months.
  • This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.

If a dose is missed:

  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you also use medicine for seizures (such as carbamazepine, phenobarbital, phenytoin, Dilantin®, Tegretol®) or steroid medicine (such as dexamethasone, hydrocortisone, methylprednisolone, prednisolone, prednisone, Medrol®).
  • Tell your doctor if you drink alcohol on a regular basis, or if you smoke or use tobacco products.

Warnings While Using This Medicine

  • Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.Use an effective form of birth control that does not contains hormones.
  • Make sure your doctor knows if you have kidney problems, epilepsy (seizures), migraine headaches, osteoporosis, vision problems, or a history of depression.
  • Tell your doctor if you have asthma, allergies (especially drug allergies), high blood pressure, diabetes, heart disease, high cholesterol, or blood clotting problems.
  • This medicine can decrease bone mineral density, which may lead to osteoporosis or weak bones. Talk with your doctor about how this risk will affect you.
  • Endometriosis symptoms may get worse for a short time when you first start using this medicine. These symptoms should get better as your body gets used to the medicine.
  • Your doctor will need to check your progress at regular visits while you are using this medicine. Be sure to keep all appointments.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Feeling depressed
  • Sudden loss of vision, double vision, bulging eyes, migraine headache
  • Sudden weight gain
  • Swelling in your hands, arms, ankles, or feet

If you notice these less serious side effects, talk with your doctor:

  • Acne
  • Headache, migraine
  • Hot flashes, warmth or redness in your face, neck, arms, or upper chest
  • Mood swings, feeling nervous or sad
  • Nausea or vomiting
  • Trouble sleeping
  • Redness, pain, swelling, or itching where the shot was given
  • Weakness, pain
  • Weight gain

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last Reviewed on 06/12/2013

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This page was last updated: September 18, 2013

         
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