Japanese encephalitis virus vaccine, inactivated adsorbed (Injection)


Japanese Encephalitis Virus Vaccine, Inactivated Adsorbed (jap-a-NEEZ en-sef-a-LYTE-is VYE-rus VAX-een, in-AK-ti-vay-ted ad-SORBD)

IXIARO® prevents Japanese encephalitis (brain fever). This is a vaccine.

Brand Name(s)


There may be other brand names for this medicine.

When This Medicine Should Not Be Used

You should not receive this vaccine if you have had an allergic reaction to Japanese encephalitis virus vaccine. This vaccine should not be given to children and teenagers younger than 17 years of age.

How to Use This Medicine


  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot into one of your muscles. It is usually given as a shot into the muscle of your upper arm.
  • A nurse or other trained health professional will give you this medicine.
  • This vaccine is given in 2 doses. Dose 2 is scheduled 28 days after Dose 1. It is very important that you receive both doses of the vaccine at least 7 days before you plan to travel out of the country.
  • If you have received the second dose of the vaccine series more than 1 year ago, consult first with your doctor. A booster dose may be given before you plan to travel out of the country.
  • This medicine comes with a patient information sheet. It is very important that you read and understand this information. Be sure to ask your doctor about anything you do not understand.

If a dose is missed:

  • If you miss the second shot, call your doctor to make another appointment as soon as possible.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are using medicines that may weaken the immune system, such as steroids (dexamethasone, prednisolone, prednisone) or cancer medicines, or if you are receiving radiation treatment.

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have bleeding problems, low platelets in the blood (thrombocytopenia), a weakened immune system, or an illness with a high fever (more than 100°F).
  • Avoid traveling to foreign countries within 7 days of the vaccine shot.
  • To prevent mosquito bites, avoid outdoor activities, and use insect repellents with protective clothing when you are outdoors during hot weather. Use mosquito nets and stay indoors during twilight and after dark.
  • This vaccine contains protamine sulfate, which may cause allergic reactions in some people. Tell your doctor if you have had an allergic reaction to protamine sulfate before you receive this vaccine.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Difficulty with breathing or wheezing.
  • Fast heartbeat.
  • Fever, chills, cough, sore throat, stuffy or runny nose, and body aches.
  • Unusual tiredness or weakness.

If you notice these less serious side effects, talk with your doctor:

  • Back pain.
  • Diarrhea, nausea, or vomiting.
  • Headache or dizziness.
  • Joint or muscle pain.
  • Pain, itching, redness, or swelling where the shot was given.
  • Rash.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last Reviewed on 06/12/2013

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