Isosorbide dinitrate (By mouth)
Isosorbide Dinitrate (eye-soe-SOR-bide dye-NYE-trate)
Treats and prevents angina (chest pain). This medicine is a nitrate.
Isordil Titradose, Dilatrate-SR
There may be other brand names for this medicine.
When This Medicine Should Not Be Used
You should not use this medicine if you have had an allergic reaction to isosorbide or similar medicines (such as nitroglycerin or Monokit®). You should not use this medicine if you are also using Viagra®.
How to Use This Medicine
Tablet, Long Acting Capsule, Long Acting Tablet, Chewable Tablet
- Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
- It is best to take this medicine on an empty stomach.
- Use this medicine exactly as directed, or it will not work properly. Most people use this medicine for only part of each day.
- Swallow the extended-release tabletor extended-release capsule whole. Do not break, crush, or chew it.
- Chew the chewable tablet completely. Hold the medicine in your mouth for a about 2 minutes before you swallow it.
- If you are using the sublingual tablet (under the tongue), sit down while taking this medicine. Wet the tablet with water or saliva. Place the tablet under your tongue and let it dissolve there. Do not chew, crush, or swallow the tablet whole. Avoid eating, drinking, or smoking while tablet is dissolving. If your chest pain lasts longer than 5 minutes, put a second tablet under your tongue. If the pain lasts another 5 minutes, use a third tablet. If your pain does not go away after the third dose, call your doctor and have someone take you to a hospital.
If a dose is missed:
- If you miss a dose or forget to use your medicine, use it as soon as you can. If your next regular dose is less than 2 hours away, wait until then to use the medicine and skip the missed dose.
- Do not use extra medicine to make up for a missed dose.
How to Store and Dispose of This Medicine
- Store the medicine at room temperature in a closed container, away from heat, moisture, and direct light.
- Keep all medicine out of the reach of children and never share your medicine with anyone.
Drugs and Foods to Avoid
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Make sure your doctor knows if you are also using diuretics or "water pills" (such as furosemide, hydrochlorothiazide, Hyzaar®), or heart or blood pressure medicine (such as verapamil, Adalat®, Calan®, Cardizem®, Lotrel®, Plendil®, Procardia®, Tiazac®).
- Do not drink alcohol while you are using this medicine.
Warnings While Using This Medicine
- Make sure your doctor knows if you are pregnant or breastfeeding, or if you have low blood pressure, congestive heart failure (CHF), an enlarged heart, or other heart problems.
- Medicines that treat chest pain sometimes cause headaches. These headaches are a sign that the medicine is working. Do not stop taking the medicine or change the time you take it in order to avoid the headaches. You may take aspirin or Tylenol® to relieve the headache. If you have severe pain, talk with your doctor.
- This medicine may make you dizzy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert. You may feel lightheaded when standing, so stand up slowly.
- Do not stop using this medicine suddenly without asking your doctor. You may need to slowly decrease your dose before stopping it completely.
Possible Side Effects While Using This Medicine
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in face or hands, swelling or tingling in the mouth or throat, tightness in chest, trouble breathing
- Blue lips or fingernails, trouble breathing
- Severe or ongoing dizziness, lightheadedness, or fainting
- Slow heartbeat, increased chest pain
- Throbbing, severe, or ongoing headache, confusion, low fever, or trouble seeing
If you notice these less serious side effects, talk with your doctor:
- Sweating, facial flushing
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
- Last Reviewed on 06/12/2013
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This page was last updated: September 18, 2013