Ifosfamide/mesna (Injection)

Introduction

Ifosfamide (eye-FOS-fa-mide), Mesna (MES-na)

Ifex® treats certain types of testicular cancer. Mesnex® protects the bladder from damage that may be caused by some cancer medicines.

Brand Name(s)

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

You should not receive this medicine if you have had an allergic reaction to ifosfamide, mesna, benzyl alcohol, or other medicines that contain sulfur. You should not receive this medicine if you are pregnant. You should not receive this medicine if you have certain severe problems with your bone marrow.

How to Use This Medicine

Kit

  • Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
  • You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed in one of your veins.
  • Drink extra liquids the day before and the day of your treatment, and every day for three days afterward.
  • Do not get the medicine on your skin. If it does, wash the area well with soap and water, and tell your caregiver.

If a dose is missed:

  • This medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • There may be certain medicines that could interact with ifosfamide/mesna. Make sure your doctor knows about all other medicines you are using.
  • Talk to your doctor before getting flu shots or other vaccines while you are receiving this medicine. Vaccines may not work as well, or they could make you ill while you are using this medicine.

Warnings While Using This Medicine

  • Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.Do not breast feed while you are being treated with this medicine.
  • Tell you doctor if you have had an allergic reaction to other medicines. Make sure your doctor knows if you have kidney problems, liver problems, bone marrow problems, or if you have recently had other chemotherapy or radiation treatments. Tell your doctor about any other illnesses or medical conditions that you have.
  • You may have bladder problems while using this medicine. If you have pink or red urine, tell your doctor right away.
  • This medicine lowers the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily. To help with these problems, avoid being near people who are sick or have infections. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.
  • Cancer medicines can cause nausea and/or vomiting in most people, sometimes even after receiving medicines to prevent it. Ask your doctor or nurse about other ways to control these side effects.If you cannot keep liquids down, call your doctor right away.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Chest pain, fast or uneven heartbeat.
  • Confusion or hallucinations (seeing things that are not there).
  • Fever, chills, or sore throat.
  • Lightheadedness or fainting.
  • Seizures.
  • Trouble urinating, pain or burning when you urinate, or pink, red, or bloody urine.
  • Uncontrollable nausea, vomiting, or diarrhea.
  • Unusual bleeding, bruising, or weakness.

If you notice these less serious side effects, talk with your doctor:

  • Back pain.
  • Drowsiness or dizziness.
  • Hair loss.
  • Headache.
  • Pain, itching, burning, swelling, or a lump under your skin where the needle is placed.
  • Upset stomach, loss of appetite, diarrhea, constipation, or mild nausea or vomiting.
  • Warmth or redness in your face, neck, arms, or upper chest.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last Reviewed on 06/12/2013

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This page was last updated: September 18, 2013

         
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