Ifosfamide (Injection)

Introduction

Ifosfamide (eye-FOS-fa-mide)

Treats cancer of the testicles.

Brand Name(s)

Ifex

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

Do not receive this medicine if you have had an allergic reaction to ifosfamide or if you have trouble urinating. Do not receive this medicine if you are pregnant or breastfeeding.

How to Use This Medicine

Injectable

  • Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given through a needle placed in one of your veins.
  • You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.
  • Drink extra fluids so you will pass more urine while you are using this medicine. This will keep your kidneys working well and help prevent kidney problems.

If a dose is missed:

  • This medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you also use St John's wort, aprepitant (Emend®), fosaprepitant (Emend® injection), rifampin (Rifadin®, Rimactane®), sorafenib (Nexavar®), medicine to treat seizures (such as carbamazepine, fosphenytoin, phenobarbital, phenytoin, Dilantin®, Luminal®, or Tegretol®), or medicine to treat a fungal infection (such as fluconazole, itraconazole, ketoconazole, Nizoral®, or Sporanox®). Tell your doctor if you have received other cancer medicines or radiation treatments.
  • Tell your doctor if you are using any medicines that make you sleepy. These include sleeping pills, cold and allergy medicine, narcotic pain relievers, and sedatives.
  • Do not eat grapefruit or drink grapefruit juice while you are using this medicine.
  • Talk to your doctor before getting flu shots or other vaccines while you are receiving this medicine. Vaccines may not work as well, or they could make you ill while you are using this medicine.

Warnings While Using This Medicine

  • This medicine can cause birth defects if it is used by the mother while she is pregnant or by the father when his sexual partner becomes pregnant. If a pregnancy occurs while you are using this medicine, tell your doctor right away.Women should not become pregnant during therapy and men should not father a child while receiving this medicine and for 6 months after stopping it.
  • Make sure your doctor knows if you have kidney disease, liver disease, anemia, bones or bone marrow problems, brain disease, heart disease, lung problems, urinary tract problems, or any type of infection.
  • This medicine lowers the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily. To help with these problems, avoid being near people who are sick or have infections. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.This medicine may slow wound healing.
  • Tell your doctor right away if you have vision changes, confusion, dizziness, hallucinations, mood changes, seizures, or unusual tiredness while using this medicine. These may be symptoms of a serious brain disease, which can be caused by this medicine.
  • This medicine may make you dizzy or drowsy. Do not drive, use machines, or do anything else that could be dangerous until you know how this medicine affects you.
  • This medicine may increase your risk of certain cancers, such as lymphoma, leukemia, and thyroid cancer. Talk to your doctor if you have concerns about this risk.
  • If you plan to have children, talk with your doctor before using this medicine. Some men and women using this medicine have become infertile (unable to have children).
  • Cancer medicines can cause nausea and/or vomiting in most people, sometimes even after receiving medicines to prevent it. Ask your doctor or nurse about other ways to control these side effects.
  • Your doctor will need to check your blood or urine at regular visits while you are using this medicine. Be sure to keep all appointments.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, or red skin rash
  • Change in how much or how often you urinate, painful or burning urination
  • Confusion, drowsiness, vision changes, hallucinations (seeing, feeling, or hearing things that are not there), or uncontrolled body movements
  • Fast, pounding, or uneven heartbeat or trouble breathing
  • Fever, chills, cough, sore throat, and body aches
  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet
  • Red or dark brown urine
  • Severe nausea, vomiting, or diarrhea
  • Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

  • Hair loss
  • Mild nausea or vomiting
  • Pain, itching, burning, swelling, or a lump under your skin where the needle is placed

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last Reviewed on 06/12/2013

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This page was last updated: September 18, 2013

         
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