Ibritumomab (Injection)

Introduction

Ibritumomab Tiuxetan (eye-bri-TOOM-oh-mab tye-UX-e-tan)

Treats non-Hodgkin lymphoma. This medicine is a monoclonal antibody that is used with other cancer medicines.

Brand Name(s)

Zevalin Y-90, Zevalin In-111

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

You should not receive this medicine if you have had an allergic reaction to ibritumomab or certain other radiation treatments, or to murine (mouse) proteins. You should not receive this medicine if you are pregnant.

How to Use This Medicine

Injectable

  • Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given through a needle placed in one of your veins.
  • You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.
  • Tell your doctor right away if any of this medicine gets on your skin or in your eyes, nose, or mouth.

If a dose is missed:

  • This medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you also use a blood thinner (such as warfarin or Coumadin®), clopidogrel (Plavix®) or a pain or arthritis medicine (such as aspirin, celecoxib, ibuprofen, naproxen, Advil®, Aleve®, Celebrex®, Motrin®, or Orudis®).
  • Talk to your doctor before getting flu shots or other vaccines while you are receiving this medicine. Vaccines may not work as well, or they could make you ill while you are using this medicine.

Warnings While Using This Medicine

  • Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away. You should not become pregnant while you receive this medicine and for 12 months after you stop it.
  • Do not breastfeed while you receive this medicine.
  • This medicine lowers the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily. To help with these problems, avoid being near people who are sick or have infections. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.
  • This medicine may cause an infusion reaction, which can be life-threatening. Tell your doctor right away if you have fever, chills, trouble breathing, chest tightness, rash, swelling in your face or hands, fainting, or lightheadedness within a few hours after you receive the medicine.
  • Tell the doctor right away if you notice redness, pain, or swelling at the place of injection.
  • Serious skin reactions can occur with this medicine. Tell your doctor right away if you have blistering or loosening of skin; red, swollen, or scaly skin; sores; or fever or chills.
  • Some of the side effects with this medicine may appear up to 4 months after you have stopped using it.
  • You may be exposed to radiation while you use this medicine. Talk with your doctor if you have concerns about this.
  • This medicine contains albumin, which is made from donated human blood. The risk of getting a virus from medicines made from human blood is low. Talk to your doctor if you have concerns about this.
  • Cancer medicines can cause nausea and/or vomiting in most people, sometimes even after receiving medicines to prevent it. Ask your doctor or nurse about other ways to control these side effects.
  • Your doctor will need to check your blood at regular visits while you are using this medicine. Be sure to keep all appointments.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, or red skin rash
  • Bloody or black, tarry stools
  • Chest pain or trouble breathing
  • Difficult or painful urination
  • Fever, chills, cough, runny or stuffy nose, sore throat, and body aches
  • Lightheadedness, dizziness, or fainting
  • Pain, redness, itching, or swelling where the needle is placed
  • Swelling in your face, hands, ankles, or feet
  • Unusual bleeding, bruising, tiredness, or weakness

If you notice these less serious side effects, talk with your doctor:

  • Mild skin rash
  • Nausea, vomiting, diarrhea, or stomach pain

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last Reviewed on 06/12/2013

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This page was last updated: June 18, 2013

         
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