Hydroxyzine (Injection)


Hydroxyzine Hydrochloride (hye-DROX-i-zeen hye-droe-KLOR-ide)

Treats anxiety, tension, severe agitation, nausea and vomiting, allergies, skin rash, hives, and itching. Also treats alcohol withdrawal, and anxiety or tension before surgery. This medicine is an antihistamine.

Brand Name(s)

Restall, Vistacot

When This Medicine Should Not Be Used

How to Use This Medicine


  • Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot into one of your muscles.
  • A nurse or other health provider will give you this medicine.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.
  • Do not drink alcohol while you are using this medicine.

Warnings While Using This Medicine

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
  • This medicine may make you drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Pain, swelling, redness, or tenderness where the shot is given.
  • Twitching or muscle movements you cannot control.

If you notice these less serious side effects, talk with your doctor:

  • Dry mouth.
  • Headache.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last reviewed on 11/18/2015

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