Hydrocortisone/lidocaine (Rectal)


Hydrocortisone (hye-droe-KOR-ti-sone), Lidocaine (LYE-doe-kane)

Treats inflammation of the rectum and anus. This medicine contains a corticosteroid.

Brand Name(s)

PharmaPure RX Lidocaine HCl-Hydrocortisone Acetate

When This Medicine Should Not Be Used

How to Use This Medicine

Cream, Ointment, Gel/Jelly

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • This medicine is for rectal use only. Do not get it in your eyes, nose, mouth, or ears. If it does get in these areas, rinse it off right away.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
  • Wash your hands with soap and water before and after you use this medicine.
  • This medicine comes in a single-use tube with an applicator. Throw away each tube and applicator after use.
  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines and food can affect how hydrocortisone and lidocaine work. Tell your doctor if you are also taking medicine that treats heart rhythm problems.

Warnings While Using This Medicine

  • Tell your doctor if you are pregnant or breastfeeding, or if you have liver disease or an infection of any kind.
  • This medicine may cause adrenal gland problems. It may also cause you to get infections more easily.
  • Do not use this medicine to treat a skin problem your doctor has not examined.
  • Call your doctor if your symptoms do not improve or if they get worse.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Dark freckles, skin color changes, coldness, weakness, tiredness, nausea, vomiting, weight loss
  • Weight gain around your neck, upper back, face, or waist

If you notice these less serious side effects, talk with your doctor:

  • Rectal irritation, burning, or itching

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last reviewed on 12/4/2015

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