Glyburide (By mouth)


Glyburide (GLYE-bure-ide)

Used with diet and exercise to help control blood sugar in patients with type 2 diabetes.

Brand Name(s)

Diabeta, Glynase Pres-Tab, Micronase

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

You should not use this medicine if you have had an allergic reaction to glyburide, or if you have metabolic acidosis (diabetic ketoacidosis). You should not use this medicine if you are also using bosentan (Tracleer®).

How to Use This Medicine


  • Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
  • It is best to take this medicine with breakfast or your first main meal of the day. Ask your doctor if you need to take this medicine at any other time.
  • Use only the brand of this medicine that your doctor prescribed. Different brands may not work the same way.

If a dose is missed:

  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.I

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are using a pain or arthritis medicine called an "NSAID" (such as aspirin, ibuprofen, Aleve®, or Celebrex®), medicine to treat an infection (such as chloramphenicol, ciprofloxacin, clarithromycin, gatifloxacin, isoniazid, levofloxacin, rifampin, sulfamethoxazole/trimethoprim, Bactrim®, Biaxin®, Chloromycetin®, Chloroptic®, Ciloxan®, Cipro®, Cotrim®, Levaquin®, Nydrazid®, Rifadin®, Rimactane®, Septra®, or Tequin®), an MAO inhibitor (such as Eldepryl®, Marplan®, Nardil®, or Parnate®), a blood pressure medicine (such as atenolol, metoprolol, propranolol, verapamil, Lotrel®, Norvasc®, or Toprol®), or a blood thinner (such as warfarin, Coumadin®).
  • Tell your doctor if you are using a diuretic or "water pill" (such as hydrochlorothiazide or HCTZ), a steroid medicine (such as dexamethasone, prednisolone, prednisone, or Medrol®), a phenothiazine medicine (such as prochlorperazine, Compazine®, Mellaril®, Phenergan®, Thorazine®, or Trilafon®), or a thyroid medicine (such as levothyroxine, liothyronine, Cytomel®, or Synthroid®). Make sure your doctor knows if you are also using birth control pills, estrogens (Premarin®), cyclosporine (Gengraf®, Neoral®, or Sandimmune®), disopyramide (Norpace®), fluoxetine (Prozac®), nicotinic acid (Nicobid®, Nicolar®). oral miconazole, phenytoin (Dilantin®), or probenecid (Benemid®).
  • Do not drink alcohol while you are using this medicine.
  • Make sure your doctor knows about all other medicines you are using for diabetes, including insulin.

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have heart problems, kidney disease, liver disease, or problems with your adrenal or pituitary gland. Tell your doctor if you also have a condition called glucose-6-phosphate dehydrogenase (G6PD) deficiency.
  • This medicine may not work as well if you have surgery, get hurt, or get sick. If you have severe vomiting, diarrhea, or fever, call your doctor for instructions.
  • You may develop low blood sugar while you are using this medicine. You may feel weak, drowsy, confused, anxious, or very hungry. You may have trouble seeing or have a headache that won't go away. Ask your doctor what you should do if this happens. Some things that can lead to low blood sugar are exercising more than normal or waiting too long to eat.
  • Tell your doctor if you start having trouble controlling your blood sugar after you use this medicine for awhile.
  • Your doctor will need to check your blood or urine at regular visits while you are using this medicine. Be sure to keep all appointments..
  • This medicine may make your skin more sensitive to sunlight. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds.
  • You may have blurred vision or trouble seeing while you are using this medicine. Avoid driving, using machines, or doing anything else that could be dangerous if you cannot see well.
  • This medicine is only part of a complete program for controlling diabetes. You can also help yourself by eating a healthy diet, watching your weight, and getting regular exercise.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Confusion, weakness, and muscle twitching.
  • Dark-colored urine or pale stools.
  • Dry mouth, increased thirst, or decrease in how much you urinate.
  • Fever, chills, cough, sore throat, and body aches.
  • Nausea, vomiting, loss of appetite, or pain in your upper stomach.
  • Seizures, fainting.
  • Swelling in your face, ankles, or hands.
  • Unusual bleeding, bruising, or weakness.
  • Yellowing of your skin or the whites of your eyes.

If you notice these less serious side effects, talk with your doctor:

  • Blurred vision.
  • Heartburn, gas, or feeling "full".
  • Joint or muscle pain.
  • Skin rash, itching, or redness of the skin.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last Reviewed on 06/12/2013

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This page was last updated: June 18, 2013

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