Glipizide/metformin (By mouth)


Glipizide (GLIP-i-zide), Metformin Hydrochloride (met-FOR-min hye-droe-KLOR-ide)

Used with diet and exercise to help control blood sugar in patients with type 2 diabetes.

Brand Name(s)


There may be other brand names for this medicine.

When This Medicine Should Not Be Used

You should not use this medicine if you have had an allergic reaction to glipizide or metformin, if you have kidney disease or metabolic acidosis (diabetic ketoacidosis), or if you are also using medicine for congestive heart failure.

How to Use This Medicine


  • Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.
  • It is best to take this medicine with food or milk.
  • To best manage your diabetes, carefully follow your doctor's instructions about any special diet, exercise, or weight loss. Test your blood sugar regularly.
  • This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.

If a dose is missed:

  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Many medicines can raise or lower your blood sugar. Tell your doctor about ALL other medicines you are using while taking glipizide/metformin. It is especially important to let your doctor know whenever you start or stop any other medicine.
  • Make sure your doctor knows if you are also using a pain or arthritis medicine called an "NSAID" (such as aspirin, Aleve®, Feldene®, Indocin®, Orudis®, Relafen®, or Voltaren®), medicine to treat an infection (such as chloramphenicol, fluconazole, isoniazid, oral miconazole, sulfamethoxazole/trimethoprim, vancomycin, Bactrim®, Chloromycetin®, Cotrim®, Diflucan®, Nydrazid®, Proloprim®, Septra®, Trimpex®, Vancocin®, or Vancoled®), an MAO inhibitor (such as Eldepryl®, Marplan®, Nardil®, or Parnate®), a blood pressure medicine (such as atenolol, metoprolol, nifedipine, verapamil, Adalat®, Corgard®, Lotrel®, Norvasc®, Procardia®, or Toprol®), or a blood thinner (such as warfarin, Coumadin®).
  • Tell your doctor if you are using a diuretic or "water pill" (such as amiloride, furosemide, hydrochlorothiazide [HCTZ], triamterene, Dyrenium®, Lasix®, or Midamor®), a steroid medicine (such as dexamethasone, prednisolone, prednisone, or Medrol®), a phenothiazine medicine (such as prochlorperazine, Compazine®, Mellaril®, Phenergan®, Thorazine®, or Trilafon®), or a thyroid medicine (such as levothyroxine, liothyronine, Cytomel®, or Synthroid®). Make sure your doctor knows if you are also using birth control pills, estrogens (Premarin®), cimetidine (Tagamet®), digoxin (Digitek®, Lanoxin®), morphine, nicotinic acid (Nicobid®, Nicolar®). phenytoin (Dilantin®), probenecid (Benemid®), procainamide (Procanbid®), quinidine, quinine, or ranitidine (Zantac®).
  • Make sure your doctor knows about all other medicines you are using for diabetes, including insulin.
  • Do not drink alcohol while you are using this medicine.

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have heart disease, kidney disease, liver disease, or problems with your adrenal or pituitary gland. Tell your doctor if you also have a condition called glucose-6-phosphate dehydrogenase (G6PD) deficiency.
  • This medicine may cause a rare, but serious condition called lactic acidosis in some people. Call your doctor right away if you get sick, or if you have unusual tiredness, weakness, muscle pain, stomach pain, trouble breathing, fever, or nausea.
  • Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests. This medicine may interact with the dye used for an X-ray or CT scan.
  • This medicine may not work as well if you have surgery, get hurt, or get sick, especially if you have severe vomiting, diarrhea, or fever. Call your doctor for instructions.
  • You may have nausea, diarrhea, or vomiting when you first start using this medicine. If these problems go away and then come back after you have been using this medicine awhile, call your doctor.
  • You may develop low blood sugar while you are using this medicine. You may feel weak, drowsy, confused, anxious, or very hungry. You may have trouble seeing or have a headache that won't go away. Ask your doctor what you should do if this happens.
  • Tell your doctor if you start having trouble controlling your blood sugar after you use this medicine for awhile.
  • Other medicines used to treat diabetes have been known to increase the risk of heart problems. It is not known if glipizide or metformin increases your risk. Ask your doctor if you have questions about this.
  • Your doctor will need to check your blood or urine at regular visits while you are using this medicine. Be sure to keep all appointments.
  • This medicine is only part of a complete program for controlling diabetes. You can also help yourself by eating a healthy diet, watching your weight, and getting regular exercise.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Extreme thirst, decrease in how much or how often you urinate.
  • Extreme weakness, tiredness, or confusion.
  • Lightheadedness, dizziness, or fainting.
  • Rapid breathing, trouble breathing, or nausea and vomiting.
  • Seizures.

If you notice these less serious side effects, talk with your doctor:

  • Cough, sore throat, sneezing, or runny or stuffy nose.
  • Headache.
  • Mild nausea, vomiting, diarrhea, or stomach pain.
  • Muscle pain.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last Reviewed on 06/12/2013

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This page was last updated: June 18, 2013

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