Glimepiride (By mouth)


Glimepiride (glye-MEP-ir-ide)

Treats type 2 diabetes. Used together with a proper diet and exercise to help control high blood sugar. This medicine is a sulfonylurea.

Brand Name(s)


There may be other brand names for this medicine.

When This Medicine Should Not Be Used

Do not use this medicine if you have had an allergic reaction to glimepiride or a sulfonamide drug (sulfa drug), such as sulfamethoxazole, Bactrim®, or Septra®.

How to Use This Medicine


  • Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.
  • It is best to take this medicine with food or milk.Take this medicine with breakfast or the first meal of the day.
  • Carefully follow your doctor's instructions about any special diet, exercise, or weight loss program. Test your blood sugar regularly.

If a dose is missed:

  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using other medicines that treat diabetes (such as insulin, glimepiride, glyburide, metformin, pramlintide, Actos®, Janumet®, Januvia®) or certain blood pressure medicines (such as atenolol, clonidine, enalapril, guanethidine, lisinopril, metoprolol, propranolol, Lotrel®).
  • Tell your doctor if you are also using an NSAID pain or arthritis medicine (such as aspirin, diclofenac, ibuprofen, naproxen, Advil®, Aleve®, Celebrex®, Voltaren®), medicine to treat an infection (such as clarithromycin, ciprofloxacin, doxycycline, sulfamethoxazole/trimethoprim, Bactrim®, Levaquin®), a blood thinner (such as warfarin, Coumadin®, Jantoven®), a steroid medicine (such as hydrocortisone, methylprednisolone, prednisolone, prednisone), a phenothiazine medicine (such as promethazine, Phenergan®, or Thorazine®), a diuretic (water pill, such as hydrochlorothiazide [HCTZ], furosemide, torsemide, Lasix®), birth control pills, or an MAO inhibitor (such as Eldepryl®, Marplan®, Nardil®, or Parnate®).
  • Tell your doctor if you are also using disopyramide (Norpace®), fluoxetine (Prozac®), isoniazid (Nydrazid®), niacin (Niaspan®), chloramphenicol, phenytoin (Dilantin®), probenecid (Benemid®), fluconazole, miconazole, rifampin, thyroid medicine, cyclophosphamide (Cytoxan®), danazol (Danocrine®), diazoxide, pentoxifylline (Trental®), phenobarbital (Luminal®), propoxyphene (Darvon®), reserpine, or somatropin (Nutropin®).
  • Make sure you doctor knows if you are using stomach medicine (such as cimetidine, famotidine, ranitidine, Pepcid®, Tagamet®, Zantac®), cholesterol medicine (such as fenofibrate, gemfibrozil, or Lopid®), HIV/AIDS medicine (such as atazanavir, lopinavir, ritonavir, Kaletra®), medicine to treat mental illness (such as clozapine, olanzapine, Clozaril®, Zyprexa®), or medicine to treat asthma (albuterol, terbutaline, Brethine®).
  • Do not drink alcohol while you are using this medicine.

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, liver problems, heart or blood vessel disease, or adrenal or pituitary problems. Tell your doctor if you also have glucose-6-phosphate dehydrogenase (G6PD) deficiency.
  • Do not use this medicine to treat type 1 diabetes or metabolic acidosis (including diabetic ketoacidosis).
  • You may develop low blood sugar while you are taking this medicine. You may feel weak, drowsy, confused, anxious, or very hungry. You may have trouble seeing or have a headache that won't go away. Tell your doctor if this happens. Low blood sugar may be caused by excess exercise or waiting too long to eat. Severe low blood sugar may reduce your concentration and ability to react. It may also cause seizures and fainting, and it may be life threatening.
  • This medicine may make you dizzy or drowsy. Do not drive, use machines, or do anything else that could be dangerous until you know how this medicine affects you.
  • Your doctor will need to check your blood or urine at regular visits while you are using this medicine. Be sure to keep all appointments. You will also need to check your blood sugar regularly at home.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, red skin rash
  • Dizziness, shakiness, hunger, lightheadedness, faint, cold sweats, or confusion
  • Fast, pounding, or uneven heartbeat
  • Shortness of breath or troubled breathing, or yellow skin or eyes
  • Unusual tiredness or weakness

If you notice these less serious side effects, talk with your doctor:

  • Headache
  • Mild dizziness
  • Mild nausea

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last Reviewed on 06/12/2013

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This page was last updated: June 18, 2013

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