Gemifloxacin (By mouth)


Gemifloxacin Mesylate (jem-i-FLOX-a-sin MES-i-late)

Treats lung infections. This medicine is a fluoroquinolone antibiotic.

Brand Name(s)


There may be other brand names for this medicine.

When This Medicine Should Not Be Used

You should not use this medicine if you have had an allergic reaction to gemifloxacin or to any other fluoroquinolone antibiotic (such as ciprofloxacin, gatifloxacin, levofloxacin, moxifloxacin, norfloxacin, ofloxacin, Avelox®, Cipro®, Floxin®, Levaquin®, Noroxin®, or Zymar®). This medicine should not be used in patients who have myasthenia gravis. This medicine should not be given to anyone younger than 18 years of age.

How to Use This Medicine


  • Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
  • You may take this medicine with or without food. Do not take this medicine alone with milk, yogurt, or other dairy products. Do not drink any juice with added calcium when you take this medicine. You may have dairy products or juice as part of a larger meal when you take this medicine.
  • Swallow the tablet whole. Do not crush, break, or chew it.
  • If you use antacids, didanosine (Videx®), sucralfate (Carafate®), or mineral supplements and multivitamins with iron or zinc, take them at least 3 hours before or 2 hours after you take gemifloxacin.
  • Keep using this medicine for the full treatment time, even if you feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon.
  • Drink extra fluids so you will pass more urine while you are using this medicine. This will keep your kidneys working well and help prevent kidney problems.
  • This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the Medication Guide if you do not have one.

If a dose is missed:

  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you use a steroid medicine (such as dexamethasone, methylprednisolone, prednisone, prednisolone, Decadron®, or Medrol®). Your chance of having tendon problems increase if you use this medicine together with steroids.
  • Make sure your doctor knows if you also use cisapride (Propulsid®), erythromycin (Ery-tab®), probenecid (Benemid®, Col-Probenecid®, Probalan®), a blood thinner (such as warfarin, Coumadin®), a hormone replacement treatment, medicine for depression (such as amitriptyline, imipramine, Norpramin®, or Vivactil®), or medicine for heart rhythm problems (such as amiodarone, disopyramide, dofetilide, procainamide, quinidine, sotalol, Betapace®, Cordarone®, Cardioquin®, Procan®, Procanbid®, Pronestyl®, Quinaglute®, or Quinidex®).
  • Tell your doctor if you use a phenothiazine medicine (such as Compazine®, Phenergan®, Serentil®, or Thorazine®). Make sure your doctor knows if you also use antacids that contain magnesium or aluminum (such as Maalox®, Mylanta®), iron supplements, multivitamins with iron or zinc, didanosine (Videx®), or sucralfate (Carafate®).

Warnings While Using This Medicine

  • Make sure your doctor knows if you are pregnant or breastfeeding or if you have kidney disease, liver disease, low potassium or magnesium in the blood, heart disease, heart rhythm problems (such as QT prolongation), or a recent heart attack. Make sure your doctor knows if you are receiving dialysis, or if you have nerve problems or a history of seizures, epilepsy, head injury, or stroke.
  • Call your doctor right away if you have any symptoms that concern you, such as unusual or severe skin rash; changes in the color of your urine or stool; changes in how much or how often you urinate; nausea; vomiting; joint or muscle pain; severe stomach pain; swelling of your face, fingers, feet, or lower legs; trouble breathing; or unusual bleeding, bruising, or weakness. Stop taking this medicine and check with your doctor immediately if you notice any of these warning signs.
  • Tell your doctor right away if you start having numbness, tingling, or burning pain in your hands, arms, legs, or feet. These may be symptoms of a condition called peripheral neuropathy.
  • If you have severe diarrhea, ask your doctor before taking any medicine to stop the diarrhea. It may occur 2 months or more after you stop using this medicine.
  • This medicine may make your skin more sensitive to sunlight. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds.
  • This medicine may rarely cause inflammation or tearing of a tendon (the cord that attaches muscles to bones). This can occur while you are taking the medicine or after you finish taking it. Your risk is increased if you are older than 60 years of age, use steroid medicines, have severe kidney problems, have a history of tendon problems (such as rheumatoid arthritis), or have received an organ transplant (such as heart, kidney, or lung). Stop using this medicine and check with your doctor right away if you have sudden pain or swelling in a tendon after exercise such as ankle, back of the knee or leg, shoulder, elbow, or wrist), bruise more easily after an injury, or are not able to put weight on or move the affected area. Do not exercise until your doctor says it is all right.
  • This medicine may make you dizzy, drowsy, or lightheaded. Do not drive, use machines, or do anything else that could be dangerous until you know how this medicine affects you.
  • If your symptoms do not improve or if they get worse, call your doctor.
  • Your doctor will need to check your blood or urine at regular visits while you are using this medicine. Be sure to keep all appointments.
  • Use this medicine only to treat the infection your doctor has prescribed it for. Do not use this medicine for any infection that has not been checked by a doctor.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, or red skin rash
  • Change in how much or how often you urinate
  • Change in the color of your urine or stool
  • Confusion, unusual thoughts or behavior
  • Diarrhea that may be bloody
  • Fast, slow, pounding, or uneven heartbeat
  • Fever
  • Lightheadedness, dizziness, or fainting
  • Muscle or joint pain
  • Nausea, vomiting, loss of appetite, or pain in your upper stomach
  • Numbness, tingling, weakness, or burning pain in your hands, arms, legs, or feet
  • Seizures or feeling shaky, restless, or nervous
  • Swelling or sudden pain in your shoulder, elbow, hand, wrist, or in the back of your knee or ankle
  • Trouble breathing
  • Unusual bleeding, bruising, tiredness, or weakness
  • Yellowing of your skin or the whites of your eyes

If you notice these less serious side effects, talk with your doctor:

  • Headache
  • Mild nausea, vomiting, diarrhea, or stomach pain
  • Mild skin rash

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last Reviewed on 06/12/2013

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This page was last updated: September 18, 2013

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