Fluconazole (By mouth)

Introduction

Fluconazole (floo-KON-a-zole)

Prevents and treats certain fungus infections. Belongs to a class of drugs called antifungals.

Brand Name(s)

Diflucan

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

You should not use this medicine if you have had an allergic reaction to fluconazole or other similar medicines such as itraconazole (Sporanox®), ketoconazole (Nizoral®), or voriconazole (Vfend®). Do not use this medicine if you are receiving astemizole (Hismanal®), cisapride (Propulsid®), pimozide (Orap®), quinidine (Cardioquin®, Quinaglute®), or terfenadine (Seldane®). You should not use the oral liquid if you have a hereditary condition where you cannot digest certain sugars (such as fructose malabsorption, glucose/galactose malabsorption, or sucrase-isomaltase deficiency). Do not use this medicine if you are pregnant.

How to Use This Medicine

Liquid, Tablet

  • Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
  • Shake the oral liquid well just before each use. Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.
  • You may take this medicine with or without food.
  • Keep using this medicine for the full treatment time, even if you feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon.
  • This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.

If a dose is missed:

  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. The mixed oral liquid should be kept in the refrigerator or at room temperature and used within 14 days. Do not freeze.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are using cimetidine (Tagamet®), erythromycin (E-Mycin®, Eryc®, Ery-Tab®), isoniazid (Nydrazid®), midazolam (Versed®), prednisone (Orasone®), rifabutin (Mycobutin®), rifampin (Rifadin®, Rimactane®), theophylline (Theo-Dur®), triazolam (Halcion®), valproic acid (Depakene®), or voriconazole (Vfend®). Tell your doctor if you are also using a blood thinner (such as warfarin, Coumadin®), a diabetes medicine that you take by mouth (such as glipizide, glyburide, tolbutamide, Diabeta®, Glucotrol®, or Orinase®), medicine to treat depression (such as amitriptyline, nortriptyline, Elavil®, or Pamelor®), medicine to treat seizures (such as carbamazepine, phenytoin, Dilantin®, or Tegretol®), or birth control pills.
  • Tell your doctor if you are using medicine that weaken the immune system (such as cyclosporine, sirolimus, tacrolimus, Gengraf®, Neoral®, Prograf®, Rapamune®, or Sandimmune®), medicine to treat HIV/AIDS (such as saquinavir, zidovudine, Fortovase®, Invirase®, or Retrovir®), or narcotic pain medicines (such as alfentanil, fentanyl, methadone, Alfenta®, Dolophine®, or Sublimaze®).
  • Make sure your doctor knows if you are using a diuretic or "water pill" (such as hydrochlorothiazide [HCTZ]), certain blood pressure medicines (such as amlodipine, felodipine, isradipine, losartan, nifedipine, Adalat®, Cozaar®, DynaCirc®, Norvasc®, or Plendil®), medicine to lower cholesterol (such as atorvastatin, fluvastatin, simvastatin, Lipitor®, Lescol®, or Zocor®), pain or arthritis medicine (such as celecoxib, diclofenac, flurbiprofen, ibuprofen, lornoxicam, meloxicam, naproxen, Aleve®, Ansaid®, Celebrex®, Mobic®, Motrin®, Voltaren®, or Xefo®), medicine to treat malaria (halofantrine, Halfan®), cancer medicines (such as cyclophosphamide, vinblastine, vincristine, Cytoxan®, Oncovin®, Velban®, or Vincasar®), or Vitamin A supplements.

Warnings While Using This Medicine

  • Using this medicine for a long time or using it too much while you are pregnant (especially during the first trimester) can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using this medicine, tell your doctor right away.
  • Make sure your doctor knows if you are breastfeeding, or if you have kidney disease, liver disease, heart disease, or heart rhythm problems (such as QT prolongation). Tell your doctor if you have cancer or HIV/AIDS.
  • Stop using this medicine and check with your doctor right away if you or your child have pain or tenderness in the upper stomach; pale stools; dark urine; loss of appetite; nausea; unusual tiredness or weakness; or yellow eyes or skin. These could be symptoms of a serious liver problem.
  • This medicine may rarely cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Stop taking this medicine and call your doctor right away if you or your child have a rash, itching, hives, hoarseness, trouble with breathing, trouble with swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.
  • Serious skin reactions can rarely occur during treatment with this medicine. Check with your doctor right away if you or your child start having a skin rash, itching, or any other skin changes while you are using this medicine.
  • This medicine can rarely cause changes in heart rhythms, such as a condition called QT prolongation. It may change the way your heart beats and cause fainting or serious side effects in some patients. Check with your doctor right away if you or your child have any symptoms of heart rhythm problems, such as fast, pounding, or uneven heartbeats.
  • This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
  • Your doctor will need to check your progress at regular visits while you are using this medicine. Be sure to keep all appointments. Blood and urine tests may be needed to check for unwanted effects.
  • If your symptoms do not improve or if they get worse, call your doctor.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Blistering, peeling, or red skin rash.
  • Dark-colored urine or pale stools.
  • Dry mouth, increased thirst, or muscle cramps.
  • Fast, pounding, or uneven heartbeat.
  • Nausea, vomiting, loss of appetite, or pain in your upper stomach.
  • Swelling in your hands, ankles, or feet.
  • Unusual bleeding, bruising, or weakness.
  • Yellowing of your skin or the whites of your eyes.

If you notice these less serious side effects, talk with your doctor:

  • Bad or unusual taste in your mouth.
  • Diarrhea.
  • Headache or dizziness.
  • Mild nausea, stomach pain, or upset stomach.
  • Mild skin rash.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Version Info

  • Last Reviewed on 06/12/2013

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This page was last updated: September 18, 2013

         
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